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PerkinElmer, Zyomyx, Affymetrix, IatroQuest


PerkinElmer received US Patent No. 6,631,211, “Interactive system for analyzing scatter plots.” The patent covers a system that can be used to analyze data from microarray experiments. A scanner system analyses data plotted in accordance with user-specified criteria or statistical measures from the data population, to produce a scatter plot that displays boundaries for the selection of outlier points and/or otherwise visually denotes in the plotted data which points are the outlier points. The scanner system analyzes the underlying data based on user-specified differential expression ratios, or based on criteria associated with the statistics of the data population, to produce outlier boundaries that are represented by diverging lines. Alternatively, the system may analyze the underlying data based on absolute expression levels, to produce boundaries that are represented in the plot by lines that meet at an identity line of slope 1. The scanner system may also combine several criteria and produce boundaries that denote as outliers the data that, for example, show both sufficient differential expression and also include individual expressions that are sufficiently above an associated noise floor.

Zyomyx received US Patent No. 6,630,358, “Arrays of proteins and methods of use thereof.” The patent covers protein arrays technology and methods for the parallel, in vitro screening of biomolecular activity. The arrays include a number of proteins immobilized on one or more organic thin films on the substrate surface.

Affymetrix received US Patent No. 6,630,308, “Methods of synthesizing a plurality of different polymers on a surface of a substrate.” The patent covers a method and apparatus for preparation of a substrate containing photoremovable elements. In the method provided, selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.

IatroQuest of Ontario received US Patent No. 6,630,356, “Photoluminescent semiconductor materials.” The patent covers a method of manufacturing semiconductor materials with a porous texture, modified with a recog-nition element, to produce a photoluminescent response on exposure to electromagnetic radiation. The recog-nition elements, selected from biomolecular, organic, and inorganic elements, interact with a target analyte to produce a modulated photoluminescent response.


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