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PerkinElmer, BioArray Solutions, BioMerieux

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PerkinElmer has received US Patent No. 7,335,338, “Method and apparatus for automatic pin detection in microarray spotting instruments.” The patent claims a method and apparatus for automatically sensing the presence or absence of spot dispensers such as pins in various possible mounting locations in the printhead of a microarray spotting instrument. Pin-location data obtained by the method and apparatus is provided to the computer controller of the instrument, which uses the data to control the motion of the printhead during operation of the instrument.
 

 
PerkinElmer has also received US Patent No. 7,335,470, “Compilations of nucleic acids and arrays and methods of using them.” The patent claims a method for selecting a genomic nucleic acid segment for use as a hybridization target in a comparative genomic hybridization reaction for the detection of a chromosomal aneuploidy. The method works by: a) selecting a chromosomal segment that hybridizes to the aneuploidy to be detected; b) selecting a chromosomal segment having at least 15 percent to 25 percent unique sequence such that at least 75 percent to 85 percent of the sequence within the chromosomal segment is repetitive, except for chromosomal segments from the X chromosome or Y chromosome, which can have up to 90 percent to 95 percent repetitive sequences; and c) selecting a segment selected in both step a) and step b), thereby selecting a genomic nucleic acid segment for use as a hybridization target in a comparative genomic hybridization reaction for the detection of a chromosomal aneuploidy.
 

 
BioArray Solutions of Warren, NJ, has received US Patent No. 7,335,153, “Arrays of microparticles and methods of preparation thereof.” The patent claims high-unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The chips described may be useful for chemical and biological assays.
 

 
BioMerieux has received US Patent No. 7,335,472, “Method for simultaneously detecting hybridization reactions and immuno-reactions, and its uses in diagnosis.” The patent claims a method for simultaneously detecting hybridization reactions and immunoreactions in a sample by: a) depositing a known amount of volume of the sample diluted in a reaction buffer, onto a capture surface pre-coated with the partners for capturing the target analytes; b) reacting at a temperature of between 15 degrees Celsius and 60 degrees Celsius; and c) visualizing the hybridization reactions and immunoreactions obtained. The method can be used for the detection of diseases of infectious or metabolic origin or viral origin, for the industrial diagnosis of the presence of bacteria, and for identifying and/or quantifying biological molecules, the patent states.

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