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PerkinElmer, Beckman Coulter

PerkinElmer last week launched its Constitutional Chip 4.0 microarray for array-based comparative genomic hybridization.
The new tool is a bacterial artificial chromosome array intended for identification of chromosomal gain or loss of DNA and identification of the region in which gain or loss has occurred. Specifically, the chip contains more than 5,000 BAC clones covering 25 percent of the human genome; 90 well-characterized chromosomal regions covered by more than 1,200 BAC clones; improved subtelomere coverage; and high-resolution detection of chromosomal gains and losses across the X chromosome.
The Constitutional Chip 4.0 is designed to be used with PE’s aCGH reagents, ScanArray scanners and image processing software, and SpectralWare aCGH analysis software.

Beckman Coulter last week launched the Agencourt DNAdvance System, a new extraction kit for DNA isolation and purification from mammalian tissue samples. 
The system incorporates Beckman’s Solid Phase Reversible Immobilization paramagnetic bead-based, nucleic acid purification technology. The Agencourt DNAdvance chemistry is also automated on the Beckman Coulter Biomek NXP and FXP Laboratory Automation Workstations.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.