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PE, Applera, Matrix Technologies, Nanogen, Affymetrix, Bio Merieux, Affymetrix

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PE and Applera have received US Patents No. 6,492,156-6,492,153, “Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof.” The patents cover a system for isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides as well as microarrays for nucleic acid detection. The technology provides novel peptides and proteins that affect protein phosphorylation and nucleic acid molecules encoding such peptide and protein molecules, all of which are useful in the development of human therapeutics and diagnostic compositions and methods.

Matrix Technologies of Hudson, N.H., has received US Patent No. 6,492,118, “Methods of immobilizing ligands on solid supports.” The patent covers a technology for immobilizing a ligand on a solid support substrate.

Nanogen has received US Patent No. 6,492,122, “Quantitative analysis methods on active electronic microarrays.” The patent covers a method for gene expression monitoring and normalizing the signals of individual microlocations by the use of an internal control sequence probe. The technology provides for a way to generate mRNA expression samples from populations of cells, tissues, or other biological source materials, that may differ in their physiological and/or pathological state. and generating a reusable nucleic acid transcript library from mRNA in a sample of biological material.

Affymetrix has received US Patent No. 6,491,871 “System for determining receptor-ligand binding affinity.” The patent covers a system for light-directed spatially-addressable parallel chemical synthesis, a reactor system, photoremovable protective groups, data collection and handling techniques, and a technique for screening linker molecules.

Bio Merieux of Marcy l'Etoile, France, and Affymetrix have received US Patent No. 6,489,114, “Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby.” The patent covers a process for labeling with signal amplification a ribonucleic acid (RNA), fragmenting the RNA to form RNA fragments, fixing a first ligand to a terminal phosphate located at least one of the 3' end and the 5' end of each of the RNA fragments, and binding labeling agents.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.