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Patent Watch: Jan 13, 2009


PamGene of Den Bosch, the Netherlands, has received US Patent No. 7,473,562, "Method for high-throughput integrated chemical and biochemical reactions." The patent claims methods for high-throughput monitoring of molecular reaction processes, using a substrate. The claimed substrate contains micro-channels, where each micro-channel has inlet and outlet open ends on opposing sides of the substrate. The method includes the steps of: a) contacting the micro-channels of the solid substrate with a sample; b) optionally removing excess of the sample via the outlet's open ends; c) contacting the retained analyte with at least one second reaction component under conditions that allow a molecular reaction to take place and produce a signal; and (d) detecting the signal and reading-out reaction results.

Fluidigm of South San Francisco, Calif., has received US Patent No. 7,476,363, "Microfluidic devices and methods of using same." The patent claims a microfluidic device for reacting a number of different samples with a number of different reagents. The device includes: a) a first layer; b) a second layer; and c) a number of of reaction cells located in the second layer. Each reaction cell includes: i) a first chamber located in the second layer; ii) a second chamber located in the second layer connected to the first chamber via an interface channel; and iii) a first valve in the interface channel between the first chamber and the second chamber that, when actuated, fluidically isolates the first chamber and the second chamber from each other.

Nanosphere of North Brook, Ill., has received US Patent No. 7,476,550, "Method for attachment of silylated molecules to glass surfaces." The patent claims a method for the immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as glass surfaces. Also included are compounds, devices, and kits for modifying surfaces such as glass surfaces. The method enables the attachment of molecules such as oligonucleotides onto unmodified surfaces such as a glass surface without the need for "laborious" synthetic steps, according to the abstract, but with increased surface loading densities, and with greater reproducibility and which avoids the need for pre-surface modifications.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.