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Papers of Note for American Association of Cancer Research 95th Meeting (March 27-31)


Following are selected microarray-related presentations from the proceedings of AACR, which starts Saturday in Orlando, Fla. Papers are listed by conference abstract number, title, researchers, and affiliation.

  • 58 - Response to anti-angiogenic therapy reflects tumor genotype and microenvironment. Timothy Lane, et al. University of California, Los Angeles.
  • 570 - In vivo promotion of human epithelial tumor growth mediated by Pa3-expressing fibroblasts. Yongke Zhang, et al. Protein Design Labs, Fremont, Calif.
  • 595 - Array CGH analysis of herceptin resistant breast cancer cell lines show specific areas of DNA copy changes including a deletion associated with bcl-2 suppression. Mark Basik, et al. Jewish General Hospital/McGill University, Montreal, Canada.
  • 604 - A genetic and proteomic approach to identify factors involved in Tamoxifen responsiveness. Daniel Scott, et al. Institute of Molecular Medicine and Cancer Research, University of Leeds, Leeds, UK.
  • 605 - Gene expression profiles over the progression from doxorubicin sensitivity to resistance in breast carcinoma cells indicating a spectrum of cellular responses. Nicola Turton, et al. Queensland Institute of Medical Research, Brisbane, Australia.
  • 612 - Induction of taxol-resistance by artificial transcriptional activators. Wongi Seol, et al. ToolGen, Daejeon, South Korea.
  • 615 - The regulatory role of glucosylceramide synthase on gene expression contributes to drug resistance in breast cancer cells. Yong Liu, et al. John Wayne Cancer Institute, Santa Monica, Calif.
  • 617 - Genetic analysis of proteasome-related pathways in PS-341 resistant human colon cancer cell lines. Allyson Ocean, et al. Weill Medical College of Cornell University, New York, NY.
  • 1645 - Comparison of expression profiles from oligoarray and Illumina bead-based microarray platforms. Merrill Miller, et al. NIEHS, Durham, NC and Illumina, Inc., San Diego, Calif.
  • 1647 - Development of a standardized, quantitative microarray for gene expression measurement. Erin Crawford, et al. Medical College of Ohio, Toledo, Ohio.
  • 1649 - RNA integrity number (RIN) – towards standardization of RNA quality assessment. Odilo Mueller, et al. Agilent Technologies, Karlsruhe, Germany and Agilent Technologies, Palo Alto, Calif.
  • 1651 - A comparison of RNA amplification techniques at low-input concentration. Julie Lang, et al. University of California, San Francisco Comprehensive Cancer Center, San Francisco, Calif. and Dana-Farber Cancer Institute, Harvard Medical. School, Boston, Mass.
  • 1788 - Complete p53 multi-exon sequencing by gene chip complements use of p53 immunohistochemistry for prediction of clinical outcome in invasive bladder cancer. Ben George, et al. University of Southern California, Los Angeles, Calif., and Roche Molecular Systems, Alameda, Calif.
  • 1873 - c-MET/HGF biology and signal transduction in small cell lung cancer, especially as identified through a global proteomics phospho-antibody array based approach. Patrick Ma, et al. The University of Chicago Medical Center, Chicago, Ill., Dana-Farber Cancer Institute, Boston, Mass.; Biosource International, Camarillo, Calif.
  • 1913 - Application of fluorescent bicolor in situ hybridization and computer-assisted measurement of MMP: E-cadherin ratio for prediction of metastatic potential of prostate cancer. Takamitsu Sasaki, et al. Nara Medical University Cancer Center, Kashihara, Japan.
  • 2245 - Global analysis of molecular genetic mechanisms in anticancer drug chemoresistance. Weiguang Wang, et al. Beatson Institute for Cancer Research, Glasgow, UK and University of Aberdeen, Aberdeen, UK.
  • 2248 - Gene expression profiling to predict platinum-sensitivity in ovarian cancer. Richard Drake, et al. University of Texas Southwestern Medical Center, Dallas, Texas.
  • 2252 - Microarray analysis of Alimta mechanism of action in GC3 colon carcinoma cells. Xi Lin. Lilly Research Laboratories, Indianapolis, Ind.
  • 2264 - Investigating the mechanism of cannabis-induced cytotoxicity: The role of the cannabinoid receptors. Thomas Powles, et al. New Drug Study Group, Barry Reed Oncology Lab, London, UK.
  • 2829 - Integration of high-resolution genome-wide copy number and gene expression profiling with clinical translation in bladder cancer. Saija Haapa-Paananen, et al. VTT Technical Research Centre of Finland, Turku, Finland; University of Basel, Institute of Pathology, Basel, Switzerland; Tampere University of Technology, Tampere, Finland.
  • 2857 - Gene expression profiling in prostate cancer refined by pairwise comparisons of cDNA microarrays from benign and malignant tissue. Karl Kalland, et al. University of Bergen, Bergen, Norway; Haukeland University Hospital, Bergen, Norway; Institute for Systems Biology, Seattle, Wash.
  • 3295 - Gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arrays. Marina Bibikova, et al. Illumina, San Diego, Calif., and Veridex, Johnson & Johnson, Raritan, NJ.
  • 3542 - Proteomic analysis of childhood leukemia cell lines. Laura Gunn, et al. University of California, School of Public Health, Berkeley, Calif.
  • 3549 - Protein profiling of cervical cancer by protein biochips: Proteomic scoring to discriminate cervical cancer from normal cervix. Yick Fu Wong, et al. The Chinese University of Hong Kong, and Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass.
  • 3606 - Vascular genomics using cDNA microarray for identification of angiogenesis-related genes in in vivo-mimicking model system. Ji Hye Shin, et al. Cancer Metastasis Research Center, Brain Korea 21 Project for Medical Science, Yonsei University, Seoul, South Korea, and Cancer Metastasis Research Center, Yonsei University, Seoul, South Korea.
  • 4075 - Gene expression profiles in normal human bronchial epithelial (NHBE) cells following cigarette smoke exposure. Wanda Fields, et al. R. J. Reynolds Tobacco, Winston-Salem, NC; Wake Forest University Baptist Medical Center, Winston-Salem, NC.
  • 4076 - Possible mechanistic analyses using chip array analysis on inhibited uterine tumorigenesis in rasH2 mice initiated with N-ethyl-N-nitrosourea followed by dietary treatment of ethinylestradiol. Takao Watanabe. Tokyo University of Agriculture and Technology, Fuchu, Japan.
  • 4078 - Aging-associated changes in gene expression in the ACI rat prostate: Implications for carcinogenesis. Ismael Reyes, et al. New York Medical College, Valhalla, NY; and Corporacion Universitaria Rafael Nuñez, Cartagena, Colombia.
  • 4079 - Gene expression patterns induced by 3-methylcholanthrene in rat hepatic tissues using cDNA microarray technology. Sudha Kondraganti, et al. Baylor College of Medicine, Houston, Texas; and University of Wisconsin, Madison, Wisc.
  • 4081 - Gene expression profiles in arsenic-treated MCF-7 breast cancer cells expressing different levels of HSP70. Gail Nelson, et al. US Environmental Protection Agency, Research Triangle Park, NC; and NC State University College of Veterinary Medicine, Raleigh, NC.
  • 4082 - Gene expression profiling of the rat kidney following chronic exposure (100 wks) to the water disinfectant byproduct and renal carcinogen, potassium bromate. DonDelker, et al. US Environmental Protection Agency, Durham, NC.
  • 4083 - Construction of the in-house cDNA microarray for oral cavity cancer analysis and identification of differentially expressed genes in salivary gland cancer cell lines. Morihiro Higo, et al. Departments of Clinical Molecular Biology and Functional Genomics, Graduate School of Medicine, Chiba University, Chiba, Japan; the Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokushima University, Tokushima, Japan.
  • 4797 - Bioinformatic analysis reveals an association of HOXB7 gene expression with oncogenic pathways and phenotypic properties in cancer. Sami Kilpinen, et al. Medical Biotechnology Department, VTT Technical Research Center of Finland; Biomedicum Biochip Center, Helsinki University, Helsinki, Finland.
  • 5221 - Identification and validation of androgen receptor associated transcription factor complex in human prostate cancer cells by using a novel interaction array technology. Nishit Mukhopadhyay, et al. Brigham and Women’s Hospital, Boston, Mass.; and Panomics, Redwood City, Calif.
  • 5244 - Analysis of gene expression in breast cancer cells treated with antisense raf oligonucleotide using microarrays. Rajshree Mewani, et al. Georgetown University Medical Center, Washington, DC.
  • 5583 - Expression and genome analysis of bladder cancer by microarrays identifies distinct tumor subgroups. Ekaterini Blaveri, et al. UCSF Comprehensive Cancer Center, San Francisco, Calif.
  • 5584 - Identification of a molecular signature defining disease progression in patients with superficial bladder carcinoma. Lars Dyrskjøt, et al. Aarhus University Hospital, Skejby, Aarhus, Denmark.
  • 5585 - Quantitative evaluation of a gene expression panel in matched benign and neoplastic prostate epithelial cells from patients with “high-risk” and “moderate-risk” of prostate cancer progression. Aijun Liu, et al. Center for Prostate Disease Research, Bethesda, Md.
  • 5586 - Diagnostic markers that distinguish colon and ovarian adenocarcinomas: Identification by genomic, proteomic, and tissue array profiling. Satoshi Nishizuka, et al. National Cancer Institute, NIH, Bethesda, Md.
  • 5587 - Identification of Dukes C colorectal cancer patients with poor prognosis following surgery utilizing oligonucleotide microarray analysis. Diego Arango, et al. Biomedicum Helsinki, Helsinki, Finland.
  • 5589 - Patterns of gene expression in pulmonary fine needle aspirates (FNA) with diverse radiographic appearances. Maureen Lane, et al. Weill Medical College of Cornell University, New York, NY.
  • 5591 - Genome-wide characterization of oral cavity squamous cell carcinoma using aCGH and expression profiling. Marcia Brose, et al. Abramson Cancer Center at the University of Pennsylvania, Philadelphia, Pa.


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