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Packard BioScience, Packard Instruments, PerkinElmer, Samsung Electronics

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Packard BioScience, now PerkinElmer, has received two US patents. The first, Patent Number 6,362,832, “Method and system for overlaying at least three microarray images to obtain a multicolor composite image,” covers methods and systems for overlaying microarray images from a microarray scanner to get a multicolor image displayed on a computer screen. The second, US Patent Number 6,362,004, “Apparatus and method for using fiducial marks on a microarray substrate,” refers to a microarray scanner that aligns the microarray using a reference mark on the array.

 

Packard Instruments, also now PerkinElmer, has received US Patent Number 6,361,745, “Microarray storage device for use in an automated microarray handling system.” The device includes a cassette with openings at the ends, and has parallel rails along its walls in which microarrays can be held. Springs in the side walls press down on the margins to hold the arrays in their compartments. The cassette is designed to be attached to a platform of a microwave handling system.

 

Samsung Electronics has received US Patent Number 6,359,125, “Process for preparing peptide nucleic acid probe using polymeric photoacid generator.” The invention covers a method that used a polymeric photoacid generator to make arrays with neutral peptide nucleic acid probes on a solid matrix, instead of negatively charged oligonucleotide probes. These preparation steps include 1) derivatizing the surface of the matrix with aminoalkyloxysilane in alcohol and attaching to the surface a linker with acid-labile protecting group, 2) coating the matrix with polymeric photoacid generator, 3) exposing the matrix to light to generate acid in order to eliminate the acid-labile protecting group; 4) washing the matrix with alkaline solution or organic solvent to remove residual polymeric photoacid generator; and 5) attaching a monomeric peptide nucleic acid with acid-labile protecting group to the solid matrix, then repeating steps two to five.

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