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Packard Bioscience, Affymetrix, PE Corporation, Genomic Solutions

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Packard Bioscience (now PerkinElmer) has received US Patent Number 6,441,379, “Imaging system for an optical scanner.” The system comprises a radiation device for at least two different wavelengths, a lens for focusing, and a mirror such that the emission is directed to a detector and the collimated excitation is directed away from the detector.

Affymetrix has been awarded US Patent Number 6,440,667, “Analysis of target molecules using an encoding system.” The invention provides methods and apparatus for sequencing, fingerprinting, and mapping biological macromolecules. The methods make use of sequence specific recognition reagents, which can also be used for classification of biological samples and to characterize their sources.

PE Corporation has received US Patent Number 6,440,217, “Apparatus and method for spotting a substrate.” The invention provides a method and apparatus for dispensing a small volume of a selected liquid onto a substrate. The device includes a tube adapted to contain the liquid. An elongate fiber is disposed within the tube for axial movement between raised and lowered positions. Upon shifting or oscillating the fiber, a liquid spot can be formed at a selected position on the substrate. The device is readily adaptable for the production of microarrays.

Genomic Solutions (soon to merge with Harvard Bioscience) has received US Patent Number 6,432,696, “Thermal and fluidic cycling device for nucleic acid hybridization.” The apparatus includes a fluid control module and a temperature control module for precisely controlling fluid contacting and temperature of DNA samples. The DNA samples are typically arrayed on solid substrates, and the apparatus can process up to twelve slides at one time on a master unit; satellite units can be added to increase the number of slides. All slides can be processed in parallel.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.