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Oxford Gene Technology, ExonHit Therapeutics, Agilent Technologies

Oxford Gene Technology has added four prokaryote species its Chip² family of chromatin immunoprecipitation (ChIP)-on-chip microarray products, the company said this week.
Chip² arrays are now available for Escherichia coli 0157, Salmonella typhimurium LT2, Salmonella typhimurium SL1344, and Streptomyces coelicolor.
In May, OGT launched its first product in the Chip² portfolio, an E. coli K12 ChIP-on-chip microarray (see BAN 5/30/2006).

ExonHit Therapeutics this week launched its SpliceArray internet portal. The firm claims the online tool will enable the biomedical community to order microarrays designed to study the expression of the entire human genome.
According to ExonHit, customers will now be able to order arrays from ExonHit's new catalogue, which now offers 75 microarrays. In addition, users can access ExonHit’s genome expression map, the company said.
Finally, scientists will be able to submit their list of favorite genes in order to view the associated splicing events, and create customized microarrays. The microarrays can then be manufactured on different platforms based on agreements between ExonHit and Agilent or Affymetrix, the company said.
The SpliceArray portal can be accessed at

Agilent Technologies this week launched eArray 4.5, the latest installment of its online web tool. According to Agilent, eArray 4.5 now offers probe design capability. Agilent eArray v4.5 users can also query databases containing more than 21 million tiled comparative genomic hybridization and chromatin immunoprecipitation (ChIP)-on-chip probes, enabling them to create high-resolution arrays that target genomic regions of interest.
eArray 4.5 also contains genome-wide mouse and human ChIP probe databases, each containing 13 million probes, and mouse and human probe data sets of 8 million probes each for CGH applications. Agilent also recently added arrays for rhesus macaque, bovine, and canine species.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.