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Omron, Riken, The Regents of the University of California, Linden Technologies, Medical Discovery Partners, Kishimoto Sangyo

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Omron of Kyoto, Japan, has received US Patent No. 6,856,359, “Biochip with means for scanning light and method of reading the biochip.” The patent covers a biochip with liquid crystal cells, each corresponding to a sample, that contain polarization filters and electrodes. By applying a voltage to a desired cell, external light is selectively applied to the sample. This makes it possible to reduce the size and cost and increase the speed of a biochip reade, according to the inventors.


Riken of Japan has received US Patent No. 6,855,541, “Kit used for fabricating an integrated biomolecule sensor.” The kit includes an optical fiber bundle unit. The ends of the fibers are placed into solution containing probe polymers with different base sequences, which bind to the end of the fiber. The fiber bundle units are then joined together. To use the biosensor, the fiber bundle is immersed into a solution of nucleic acid sample labeled with a fluorophore, laser light is introduced into a selected optial fiber, and the fluorescence intensity is measured.


The Regents of the University of California in Oakland, Calif., have received US Patent No. 6,855,538, “High-efficiency microarray printing device.” The invention provides improved components, such as array pins and a print head, for microarray printing devices. In one embodiment, this invention provides a print head consisting of several glass or quartz spotting capillaries in a support that maintains a fixed spacing between the capillaries and that permits them to move in a direction parallel to the long axis of the capillaries.


Linden Technologies of Woburn, Mass., has received US Patent No. 6,855,501, “Transfer of arrayed chemical compositions.” The patent covers a method where nucleotide preparations are transferred from a one substrate to another. One transfer method involves dispensing nucleic acid subunits in a dry composition for in-situ synthesis of oligos on a first substrate, positioning the first substrate over a second one, and transferring at least a portion of the dry deposition from the first to the second substrate. The method can be used to form an array of nucleic acids.


Medical Discovery Partners of Sharon, Mass., has received US Patent No. 6,855,490, “Method for attaching biological molecules to a glass surface.” The invention describes a method for attaching biological molecules, such as proteins, nucleic acids, and carbohydrates, to a glass surface. In particular, a covalent attachment method is described wherein a glass surface is first activated with a water-stable form of an isocyanate, termed a protected isocyanate. The protecting group of the isocyanate moiety is displaced by amines, hydroxyl, or carboxyl groups of biological molecules, leading to covalent attachment to the glass surface.


Kishimoto Sangyo of Osaka, Japan, has received US Patent No. 6,855,419, “Polymer thin film, its production method, binder for biochip, biochip, and its production method.” The patent covers a method for producing a DNA chip where a DNA-binding layer is formed on a substrate. The layer is a diamond-like film with a DNA-binding group. The method comprises the steps of: reducing pressure of a vacuum chamber to a predetermined degree of vacuum; feeding the chamber with a gas which is the source of the diamond-like film; feeding the chamber with a gas which is the source of nitrogen; and forming the diamond like film with the DNA-binding group on the substrate by chemical vapor deposition. The chips can be produced simply and at a low cost. They also reduce loss of probes and sample substances in the washing step.

 

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