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Oligos Etc., Hitachi Software Engineering, Applera, Genset

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Oligos Etc. of Wilsonville, Oregon has received US Patent No. 6,562,569, “Arrays with modified oligonucleotide and polynucleotide compositions.” The patent covers methods and compositions of arrays with modified oligonucleotides that bind either DNA or RNA. The arrays either have increased binding affinity with complementary RNA, or exhibit acid resistance, enabling treatment with low pH solutions. They can also be resistant to nuclease degradation.

Hitachi Software Engineering has received US Patent 6,563,584, “Method and device for fluorescence measurement.” The patent covers the use of a continuous-wave laser as an excitation light source for detection. In the invention, he sample is irradiated with the light from the light source, then is transported to the optical axis of a fluorescent detector.

Applera has received US Patent No. 6,562,593, “Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof.” The patent describes transporter peptides encoded by specific human genes, and, in particular, isolated nucleic acid and peptide molecules as well as methods for identifying both orthologs and paralogs of these transporter peptides as well as methods of identifying transporter peptide modulators.

Genset has been awarded US Patent No. 6,559,294 , “Chlamydia pneumoniae polynucleotides and uses thereof.” The patent covers the nucleic acid sequences that encode the Chlamydia pheumoniae peptides, including cellular envelope polypeptides. It also covers antisense and ribozyme molecules that are the transcription products of this organism’s genome, and which can be used to control its growth. Additionally, the invention provides for methods of detecting the nucleic acids and kits for diagnosing infection with this organism, as well as kits for selecting compounds that can modulate infection with this bacterium.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.