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NimbleGen Systems, Invitrogen, Hitachi Sofware Engineering

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NimbleGen Systems of Madison, Wis., has received US Patent No. 7,037,659, "Apparatus for constructing DNA probes having a prismatic and kaleidoscopic light homogenizer." The patent claims an apparatus for constructing arrays of DNA sequences using the image of a micromirror array projected on a reaction site. According to the patent's abstract, the sequence is created by a uniform beam of light produced by a homogenizer formed of a prismatic refractive element followed by a kaleidoscopic element.


Invitrogen of Carlsbad, Calif., has received US Patent No. 7,037,661, "Compositions and methods for labeling of nucleic acid molecules." The patent claims compositions, kits, and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the patent describes methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced are particularly suited as labeled probes for nucleic acid detection and diagnostics, the patent claims.


Hitachi Sofware Engineering of Kanagawa, Japan, has received US Patent No. 7,035,738, "Probe designing apparatus and probe designing method." The patent describes a DNA chip, on which a plurality of different probes are prepared to one kind of bacterium. When some probes are not available after the addition of bacteria, identification is carried out using the remaining probes, the patent states. When a probe unique to an identification target bacterium cannot be designed, a probability of correct identification is increased by using multiple probes. Because the possibility that multiple kinds of bacteria simultaneously exist, a combination of probes that maximizes a probability of correct identification is selected for the chip, according to the patent.

The Scan

For Better Odds

Bloomberg reports that a child has been born following polygenic risk score screening as an embryo.

Booster Decision Expected

The New York Times reports the US Food and Drug Administration is expected to authorize a booster dose of the Pfizer-BioNTech SARS-CoV-2 vaccine this week for individuals over 65 or at high risk.

Snipping HIV Out

The Philadelphia Inquirer reports Temple University researchers are to test a gene-editing approach for treating HIV.

PLOS Papers on Cancer Risk Scores, Typhoid Fever in Colombia, Streptococcus Protection

In PLOS this week: application of cancer polygenic risk scores across ancestries, genetic diversity of typhoid fever-causing Salmonella, and more.