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NimbleGen, Affymetrix, Nanogen, VizX


NimbleGen Systems has launched services using its new ENCODE microarray, based on content generated by the Encyclopedia of DNA Elements Project Consortium. The array contains more than 384,000 unique 50mer probes selected from 30 megabases of human sequence data specified by the consortium. NimbleGen is one of two micro-array firms to participate in the ENCODE project. The launch of NimbleGen’s array follows the launch of Affymetrix’s ENCODE01 array, based on the same project, last month (see BAN 10/27/2004).

Affymetrix has introduced 179 NimbleExpress prokaryotic array designs. The arrays are manufactured by NimbleGen for Affymetrix under a pact signed earlier this year. Affymetrix said the arrays will enable researchers to study the whole-genome expression of many pathogenic organisms such as Bacillus anthracis, Haemophilus influenzae, and Mycobacterium tuberculosis.

Nanogen has announced the development of analyte-specific reagents for detecting six common respiratory viruses in a single panel. The panel includes ASRs for influenza A, influenza B, human parainfluenza 1, human parainfluenza 2, human parainfluenza 3, and respiratory syncytial virus A/B. The ASRs will run on Nanogen’s NanoChip 400, the firm’s recently introduced second-generation microarray-based instrument, and will be available to clinical labs in early 2005 (see BAN 11/3/2004 for more information).

VizX has launched the GeneSifter Jumpstart microarray data analysis package for Affymetrix GeneChip users. The package provides written reports of statistical and biological analysis of data, WebEx presentations that demonstrate how the analysis was performed, and data prepared for further analysis by GeneSifter science support staff. It also provides an option for submission of microarray data to the GEO public data repository.


The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.