NGK Insulators of Nagoya, Japan, has received US Patent Number 6,365,378, “Method for producing DNA chip.” The patent covers a method wherein a DNA fragment is amplified by PCR, then the product is dried into a DNA powder. This powder is then added to sample-pouring ports in micropipettes of a dispenser, and a buffer solution is poured from the port into a cavity to prepare a sample solution. This solution is then discharged by an actuator onto a base plate.
Qiagen of Venlo, the Netherlands, has just received US Patent Number 6,365,349, “Apparatus and methods for arraying solution onto a solid support.” The patent covers a method in which a planar tip of a spring probe is immersed into a solution of biomolecules — preferably oligonucleotides — with a thickening agent, then removed from the solution with sample adhering to the tip, and transferred to a solid support.
Zyomyx of Hayward, Calif., has been awarded US Patent Number 6,365,418, “Arrays of protein capture agents and methods of use thereof.” The patent covers Zyomyx’s arrays of protein-capture agents that are expressed in cells. It describes different antibody arrays and uses for patterns of cellular protein expression.
“The state-of-the-art protein chip technology covered in this patent is the second critical element of our emerging broad patent estate,” said Lawrence Cohen, Zyomyx chief executive officer, in a statement. “Together with the ‘Non-Specific Binding Resistant Border’ technology patent recently issued to Zyomyx, today’s patent issuance positions Zyomyx as a dominant player in the protein biochip market by giving broad exclusive rights to key surface chemistry configurations.”