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NGK Insulators, Qiagen, Zyomyx


NGK Insulators of Nagoya, Japan, has received US Patent Number 6,365,378, “Method for producing DNA chip.” The patent covers a method wherein a DNA fragment is amplified by PCR, then the product is dried into a DNA powder. This powder is then added to sample-pouring ports in micropipettes of a dispenser, and a buffer solution is poured from the port into a cavity to prepare a sample solution. This solution is then discharged by an actuator onto a base plate.


Qiagen of Venlo, the Netherlands, has just received US Patent Number 6,365,349, “Apparatus and methods for arraying solution onto a solid support.” The patent covers a method in which a planar tip of a spring probe is immersed into a solution of biomolecules — preferably oligonucleotides — with a thickening agent, then removed from the solution with sample adhering to the tip, and transferred to a solid support.


Zyomyx of Hayward, Calif., has been awarded US Patent Number 6,365,418, “Arrays of protein capture agents and methods of use thereof.” The patent covers Zyomyx’s arrays of protein-capture agents that are expressed in cells. It describes different antibody arrays and uses for patterns of cellular protein expression.

“The state-of-the-art protein chip technology covered in this patent is the second critical element of our emerging broad patent estate,” said Lawrence Cohen, Zyomyx chief executive officer, in a statement. “Together with the ‘Non-Specific Binding Resistant Border’ technology patent recently issued to Zyomyx, today’s patent issuance positions Zyomyx as a dominant player in the protein biochip market by giving broad exclusive rights to key surface chemistry configurations.”

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.