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NGK Insulators, King Faisal Specialist Hospital, Terramark Markencreation, Illumina, AstraZeneca, IMEC, Oerlikon Balzars

NGK Insulators of Nagoya, Japan, has received European Patent No. 1845157, “Array and hybridization method.” The patent describes a hybridization method suitable for using a signal probe. It also claims an array that includes a substrate, a nucleic acid probe fixed to the substrate that is hybridized with a sample to have a signal change, and at least one cavity that is filled with a specific liquid containing the sample and causing the hybridization of the nucleic acid probe with the sample. The patent claims that the array in this arrangement can effectively enhance the reproducibility and the efficiency of hybridization with the signal probe. 

King Faisal Specialist Hospital of Riyadh, Saudia Arabia, and Terramark Markencreation of Bremen, Germany, have received European Patent No. 1844143, “Method of generating translocationally active linear DNA molecules and use thereof in array formats.” The patent claims a method for producing expressionally and translationally active linear DNA molecules that can be used as protein expression cassettes and are useful for high-throughput protein expression and analysis in living cells. The method calls for PCR amplification using two primers complementary to the sequences flanking the DNA sequence of interest. The resultant PCR product contains a promoter, the DNA sequence of interest, and a termination sequence. The invention further provides different uses of these translationally active DNA cassettes, such as in protein arrays.

Illumina has received US Patent No. 7,285,384, “Parallel genotyping of multiple patient samples.” The patent describes a method of genotyping by: a) providing an array on a substrate with a surface comprising discrete sites; b) contacting the array composition with a first set of extension probes that hybridize with target nucleic acid molecules; c) contacting the extension complex with a composition comprising a nucleotide and a polymerase; and d) detecting the presence of that nucleotide, thereby determining the genotype.

AstraZeneca of Sodertalje, Sweden, has received US Patent No. 7,285,399, “Compositions and methods using the yeast YMR107W promoter.” The patent describes yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a fermentable carbon source, such as glucose, or a non-fermentable carbon source, such as ethanol, or both. Therefore, expression of nucleic acid molecules encoding a polypeptide under the control of the novel yeast promoters may be regulated by varying the level of a fermentable carbon source, or a non-fermentable carbon source, or both, the patent states. The patent also claims a method for conducting such expression experiments using microarray technology.

IMEC of Leuven, Belgium, has received US Patent No. 7,285,674, “Silane molecules with pre-activated and protein-resistant functionalities and silane films comprising such molecules.” The patent claims a silane molecule that combines pre-activated and protein-resistant functionalities in one molecule. The patent additionally claims a method for the synthesis of such a silane molecule and a method for depositing a monolayer of such silane molecules onto a substrate. Such a monolayer of silane molecules may be used in biosensors, DNA/protein microarrays or other sensor applications, the patent states.

Oerlikon Balzers of Balzers, Liechtenstein, has received US Patent No. 7,285,789, “Optical device for surface-generated fluorescence.” The patent claims a sample substrate adapted for use with electromagnetic excitation light that includes a base and a layer system. According to the patent’s abstract, the layer system includes a multilayer interference coating with at least two layers where the thicknesses of the layers ensure that light emitted by a fluorescent sample material disposed on top of the multilayer interference coating is reflected. Light directed to a fluorescent sample material disposed on the substrate will then cause light to be emitted from the sample. The layer system includes a multilayer interference coating with at least two layers where thicknesses of the layers cause separation of the excitation light from the emitted light, the abstract states.

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