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NGK Insulators, Covance, Sartorius, Maven Technologies, Toagosei

NGK Insulators of Nagoya, Japan, has received European Patent No. 1753531, “Method of producing microarray.” The patent claims a method of producing a microarray by: ejecting the liquid sample via an inkjet printer; detecting the quality of the resulting spots; and forming successful sample spots to provide a successful microarray on which the successful spots are aligned in a predetermined pattern on the carrier.

Covance of Princeton, NJ, has received European Patent No. 1756545, “Frozen tissue microarray.” The patent claims a tissue microarray with frozen tissue cores that extend from the top of the tissue microarray to a release. The release is a material through which embedding material from the tissue microarray can easily be removed, the patent’s abstract states. A stiffener is used with the release to maintain a fiat shape of the release. The tissue cores may be formed from paraffin-free frozen tissue. By using the release, cores of frozen embedding material can be easily removed from the tissue microarray during the process of inserting donor tissue cores into the embedding material of the tissue microarray, the abstract states.

Sartorius of Goettingen, Germany, has received European Patent No. 1746168, “A microarray assembly comprising a microporous membrane and an incubation chamber arrangement.” The patent describes a microarray assembly adopted for carrying out a chemical reaction, in particular a hybridization reaction. The assembly includes a microporous membrane with a plurality of different analyte-specific capture molecules attached in a microarray format. The patent also claims an incubation chamber that includes a receptacle for receiving the membrane, a sealing means for substantially encapsulating the membrane in opposition to the receptacle, and at least one inlet port for supplying a fluid to cavities in the membrane that allow fluid to flow through it.

Maven Technologies of Pasadena, Calif., has received European Patent No. 1747433, “Microarray scanning.” The patent claims an apparatus for scanning that includes a light source capable of emitting a polarized light beam, and an optical assembly having a surface adapted to allow placement of a specimen array. The scanning method works by reflecting the light beam from the light source on the surface to provide an evanescent field over a portion of the specimen array so that the portion of the specimen array in the evanescent field causes a polarization change in the light beam, the patent’s abstract states. The apparatus also includes a detector positioned to detect the polarization change in the light beam as the light beam is scanned over the specimen array.

Toagosei of Tokyo has received US Patent No. 7,186,510, “Method for evaluating uniformity of spots on an array.” The patent claims a method for evaluating a uniformity of spots on a DNA microarray. Having a plurality of spots, these spots undergo specific emissions as a result of the hybridization of target DNA and tagged probe DNA. By examining whether patterns having periodicity are manifested in a sequence, background data are obtained.

The Scan

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In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.