Plexpress has launched an ADME-Tox screening service for canine preclinical drug candidate screening.
Called TRACPack Dog Induction, Plexpress' service is based on its transcript analysis with the aid of affinity capture, or TRAC, method of gene expression analysis.
The Helsinki, Finland-based firm said in a statement that the screening service provides canine cytochrome P450 mRNA analysis using primary dog hepatocytes followed by CYP enzyme activity measurements. Hepatocytes from three separate donors are used, the firm said, generating CYP mRNA expression and protein activity data produced in line with US Food and Drug Administration recommendations for human hepatocytes.
It added that its new panel includes "all relevant CYP targets and reference genes, ready-to-analyze in a single well for high-throughput multiplexing." Additional genes can also be included according to study needs, Plexpress said.