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New Product Watch : Jul 20, 2010


Affymetrix this week launched its Axiom Custom Genotyping Arrays.

Researchers can now access Affymetrix's Axiom Genomic Database to create custom arrays containing 50,000 to as many as 2.6 million SNPs for use in genome-wide association, replication, fine mapping, and candidate gene studies, the company said.

The genomic database includes 7.4 million SNPs from the 1000 Genomes Project, the International HapMap Project, and other sources. Researchers can also combine SNPs from their own sequencing projects and other sources with Affymetrix' validated SNPs to design arrays, the firm said. The company also expects to be able to support custom array designs containing more than 5 million SNPs in the future.

Agilent Technologies last week launched its SurePrint G3 Gene Expression Microarrays, each of which provides up to a million features per standard 1-by-3-inch slide for additional throughput and increased coverage, including both coding and non-coding RNA.

Agilent's coding and non-coding RNA content includes long intergenic non-coding RNAs discovered together with the John Rinn Laboratory at the Broad Institute of MIT and Harvard. Agilent said its G3 Gene Expression Microarrays are available in catalog and custom configurations. Using the Santa Clara, Calif.-based firm's online eArray tool, customers can design arrays of 60,000 probes on each of eight arrays per slide with up to one million probes on a single array.

Eurofins MWG Operon and Genomatix last week launched a human exome array based on Roche NimbleGen sequence capture technology.

According to the companies, the array covers 282,363 target regions, representing 240,402 exonic regions and includes splice sites, 83,246 proximal promoter regions, and 678 microRNAs.

The companies said that they will use the array to support their joint whole-exome analysis service. The exome design is contained on two 2.1-million-feature NimbleGen arrays and is usually sequenced with two channels of an Illumina Genome Analyzer IIx run with 108-base-pair chemistry, they said.

NanoString Technologies last week said that it has increased the throughput of its nCounter Analysis System by expanding its multiplexing capacity to 800 gene transcripts per reaction. This additional capability allows for the high-resolution analysis of 250 additional targets from the same amount of sample, the firm said.

The nCounter Analysis System relies on digital molecular barcoding technology for detecting and counting large sets of targets in biological samples, NanoString said. The system is used for gene signature validation, translational research, pathway analysis, and validation of microarray and next-generation sequencing data.

The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.