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New Product Watch: Sep 6, 2011


Ambry Genetics last week launched its CancerArray, an exon-focused, 180,000-probe array for comparative genomic hybridization. The new chip offers genome-wide probe coverage at an average resolution of 20 kb with higher-density coverage in more than 400 known cancer-associated genes, according to the Aliso Viejo, Calif.-based firm.

Ardy Arianpour, Ambry's vice president of business development, said that the clinical laboratory expects to see "high demand" for the new array "due to the increasing amount of translational oncology research being conducted by biotech and pharmaceutical companies and academic research groups."

The content for the array was partially drawn from the Wellcome Trust Sanger Institute's Cancer Gene Census, a catalogue of genes for which mutations have been causally implicated in cancer, Ambry said. The chip is being made available to researchers as a service through the firm's lab.

Asper Biotech has updated its array-based test for Sensorineural Hearing Loss. The new version includes four additional genes – KCNQ4, TCM1, MYO15A, MYO7A — as well as a 232-kilobase deletion from GJB6 [del(GJB6-D13S1854)]. In total, the new SNHL microarray analyzes 11 genes – GJB2, GJB6, GJB3, SLC26A5, SLC26A4, MTNR1, MTTS1, KCNQ4, TCM1, MYO15A, MYO7A – and detects 246 mutations compared to 198 mutations in the earlier version.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.