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Nanogen, The University of Pennsylvania, PerkinElmer Life Sciences


Nanogen has licensed U.S Patent Number 6,355,425, “Mutations Associated with Iron Disorders” from Billups-Rothenberg and Barry Rothenberg. The patent relates to methods for detecting certain mutations related to the inherited disease hereditary hemochromatosis. HH is a disorder caused by mutations in the HFE gene that results in iron buildup in the liver and bone joints. Nanogen has exclusive rights to S65c, one of the three mutations in the HFE gene that are responsible for 94 percent of HH cases identified in the US. Nanogen has developed a protocol that uses its NanoChip workstation in screening for S65c, and plans to introduce an analyte specific reagent for this and possibly other HH mutations by the end of the year.

The University of Pennsylvania has received US Patent Number 6,399,311, “Compositions, kits, and methods for hydrodynamic stress-related regulation of gene expression.” The patent describes methods and devices for identifying genes that are spatially regulated in response to cellular hydrodynamic stress.

PerkinElmer Life Sciences has been awarded US Patent Number 6,399,299, “Amplified array analysis system.” The patent covers an array-based system that analyzes unmodified samples in which one member of a binding pair is attached to an array, the other member is included in a mixture, and a reporter molecule produces a signal when the binding pair is present on the array.

The Scan

Could Mix It Up

The US Food and Drug Administration is considering a plan that would allow for the mixing-and-matching of SARS-CoV-2 vaccines and boosters, the New York Times says.

Closest to the Dog

New Scientist reports that extinct Japanese wolf appears to be the closest known wild relative of dogs.

Offer to Come Back

The Knoxville News Sentinel reports that the University of Tennessee is offering Anming Hu, a professor who was acquitted of charges that he hid ties to China, his position back.

PNAS Papers on Myeloid Differentiation MicroRNAs, Urinary Exosomes, Maize Domestication

In PNAS this week: role of microRNAs in myeloid differentiation, exosomes in urine, and more.