Nanogen has licensed U.S Patent Number 6,355,425, “Mutations Associated with Iron Disorders” from Billups-Rothenberg and Barry Rothenberg. The patent relates to methods for detecting certain mutations related to the inherited disease hereditary hemochromatosis. HH is a disorder caused by mutations in the HFE gene that results in iron buildup in the liver and bone joints. Nanogen has exclusive rights to S65c, one of the three mutations in the HFE gene that are responsible for 94 percent of HH cases identified in the US. Nanogen has developed a protocol that uses its NanoChip workstation in screening for S65c, and plans to introduce an analyte specific reagent for this and possibly other HH mutations by the end of the year.
The University of Pennsylvania has received US Patent Number 6,399,311, “Compositions, kits, and methods for hydrodynamic stress-related regulation of gene expression.” The patent describes methods and devices for identifying genes that are spatially regulated in response to cellular hydrodynamic stress.
PerkinElmer Life Sciences has been awarded US Patent Number 6,399,299, “Amplified array analysis system.” The patent covers an array-based system that analyzes unmodified samples in which one member of a binding pair is attached to an array, the other member is included in a mixture, and a reporter molecule produces a signal when the binding pair is present on the array.