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Nanogen, California Institute of Technology, Industrial Technology Research Institute

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Nanogen of San Diego, has received US Patent No. 6,960,298, "Mesoporous permeation layers for use on active electronic matrix devices." The ptanet claims synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The permeation layers have a defined porous character, with mesopores in a size range between about 100 nanometers and about 1000 nanometers, and may also have micropores in the micrometer size range, the patent's abstract states. Also, the patent claims synthetic polymer hydrogel permeation layers which contain copolymerized attachment sites for nucleic acid probes or other biomolecules.


California Institute of Technology of Pasadena, Calif., has received US Patent No. 6,960,437, "Nucleic acid amplification utilizing microfluidic devices." The patent claims microfluidic devices and methods using them in various types of thermal cycling reactions. Specific devices include a rotary microfluidic channel and a plurality of temperature regions at different locations along the rotary microfluidic channel at which temperature is regulated. Solution can be repeatedly passed through the temperature regions such that the solution is exposed to different temperatures, the patent's abstract states. Other microfluidic devices include an array of reaction chambers formed by intersecting vertical and horizontal flow channels, with the ability to regulate temperature at the reaction chambers. The microfluidic devices can be used to conduct a number of different analyses, including various primer extension reactions and nucleic acid amplification reactions.


Industrial Technology Research Institute of Hsinchu, Taiwan, has received US Patent No. 6,960,468, "On-spot hydrophilic enhanced slide and preparation thereof." The patent claims a non-spot hydrophilic enhanced microarray made up of a substrate; a layer of hydrophobic functional groups formed by a hydrophobic copolymer where the layer is coated onto said substrate; and a biologically active material, which is immobilized onto the layer of hydrophobic functional groups.

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