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Monsanto, UT-Battelle, Packard Instrument

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Monsanto has received US Patent No. 6,448,387, “Polymeric arrays adapted for high expressing polynucleotides.” The patent covers arrays in which the molecules are arranged according to hybridization intensity. The target molecules with “a higher than average indicia of hybridization” are at a lower-density area on the “peripheral region” of the substrate. These arrays can include probes for various species of plants and animals, as well as the fungus Aspergillus nidulans, and can include more than one species on a single array.

UT-Battelle, the non-profit operating company for Oak Ridge National Labs, has received US Patent No. 6,448,064, “Integrated circuit biochip microsystem.” The patent covers a DNA biosensor that is designed to detect hybridized DNA, using DNA probes, microlasers, electro-optics, a sampling waveguide, and a biotelemetric radio frequency signal generator. The system is miniaturized and was conceived as a cost-effective and rapid way to produce biochips for nucleic acid detection.

Packard Instrument (now PerkinElmer) has won US Patent No. 6,447,723, “Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments.” The patent describes a spotting instrument with sensors that can detect whether the substrate and the reservoir are mounted for proper printing.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.