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Molecular Probes and Affymetrix


Molecular Probes of Eugene, Ore., has received US Patent No. 6,972,326, "Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes." The patent claims methods for labeling or detecting of immobilized polyamino acids, including peptides, polypeptides and proteins, on membranes and other solid supports, using fluorescent dipyrrometheneboron difluoride dyes. Such immobilized polyamino acids are labeled or detected on blots or on arrays of polyamino acids, or are attached to immobilized aptamers. The patent claims that the methods are applicable to labeling polyamino acids from biological material and that such polyamino acids may be obtained for the purposes of immunoassaying to determine the presence or location of a specific target, diagnose medical conditions, or identify disease states.

Affymetrix of Santa Clara, Calif., has received Statutory Invention Registration No. H2,136, "Nucleic acids encoding G protein-coupled receptors." The document claims GPCR polynucleotides, GPCR polypeptides, gene delivery vehicles comprising and/or expressing the GPCR polynucleotides, antibodies and fragments capable of specifically binding to the GPCR polypeptides, and modulators of the GPCR. The patent also describes the use of host cells, transgenic organisms, as the gene delivery vehicle. Methods of using these compositions for diagnosis and treatment of GPCR associated diseases are also claimed.

The Scan

Cell Atlas of Human Lung Development Gives View of Developing Airway

Researchers have generated a cell atlas of human lung development, which they report in Cell.

Study Finds Costs of Genome Sequencing May Limit Utility in Routine Care

Researchers report in the European Journal of Human Genetics that genome sequencing for rare disease diagnoses currently has similar benefits as less expensive exome analysis.

Study Suggests Nursing Mother's Diet Can Impact Offspring's Gut Microbiome

A new Cell Host and Microbe paper finds that mice whose mothers were fed a low-fiber diet during nursing experience lasting microbiota dysbiosis and increased obesity.

Study Links Genetic Risk for ADHD With Alzheimer's Disease

A higher polygenic risk score for attention-deficit/hyperactivity disorder is also linked to cognitive decline and Alzheimer's disease, a new study in Molecular Psychiatry finds.