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Molecular Machines, The Institute of Microelectronics of Singapore, SurModics, Clinical Micro Systems, BioCrystal, The Regents of the University of Michigan


Molecular Machines of Montclair, NJ, received US Patent No. 6,762,025, “Single-molecule selection methods and compositions.” The patent covers single-molecule selection methods for identifying target-binding molecules from diverse sequence and shape libraries. Single oligonucleotide molecules with desirable binding properties are selected from diverse sequence libraries and identified by amplification and sequencing. Alternatively, selected oligonucleotide molecules are identified by sequencing without amplification.

The Institute of Microelectronics of Singapore received US Patent No. 6,762,049, “Miniaturized multi-chamber thermal cycler for independent thermal multiplexing.” The patent covers a method for performing arrays of micro-chemical reactions simultaneously, but with each reaction achievable at different temperatures and/or at different times. In this technology, this is achieved by a plastic chip, or similar low cost material, containing an array of reaction chambers. After all chambers have been filled with reagents, the chip is pressed up against a substrate, typically a printed circuit board, there being a set of temperature balancing blocks between the chip and the substrate. Individually controlled heaters and sensors located between the blocks and the substrate allow each chamber to follow its own individual thermal protocol while being well thermally isolated from all other chambers and the substrate. The latter rests on a large heat sink to avoid temperature drift over time. A process for manufacturing the apparatus is also disclosed.

SurModics of Eden Prairie, Minn., received US Patent No. 6,762,019, “Epoxide polymer surfaces.” The patent covers a method and reagents for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.

Clinical Micro Systems of Pasadena, Calif., received US Patent No. 6,761,816, “Printed circuit boards with monolayers and capture ligands.” The patent covers compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.

BioCrystal of Westerville, Ohio, received US Patent No. 6,761,877, “Functionalized encapsulated fluorescent nanocrystals.” The patent covers a fluorescent nanocrystals technology and a method for using it.

The Regents of the University of Michigan received US Patent No. 6,762,022, “Compositions and methods for analysis of nucleic acids.” The patent covers a number of methods that include the creation of a nucleic acid terminated at one or more selected bases, sequence analysis of nucleic acids, mapping of sequence motifs within a nucleic acid, positional mapping of nucleic acid clones, and analysis of telomeric regions. The methods utilize double-stranded templates, and in most aspects involve a strand-replacement reaction initiated at one or more random or specific locations created in a nucleic acid molecule, and in certain aspects utilizing an oligonucleotide primer.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.