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Molecular Devices, PamGene, Corning, Affymetrix, Agilent Technologies

Molecular Devices has received US Patent No. 7,364,846, “Gene expression profiling from FFPE samples.” The patent claims a method of synthesizing cDNA from the polyadenylated RNA from cells of a formalin-fixed and paraffin-embedded sample. The method includes a) extracting RNA from the cells of an FFPE sample; b) heating the RNA at about 70 degrees Celsius for 2 to 8 hours; and c) contacting the extracted RNA with a primer. The primer is linked to a promoter sequence and includes an oligo dT sequence. A cDNA strand is consequentially synthesized.

PamGene of ‘s-Hertogenbosch, the Netherlands, has received US Patent No. 7,364,848, “Integrated microarray analysis.” The patent describes methods for identifying analyte nucleic acids present in a sample of nucleic acid molecules by: a) providing a porous substrate; b) immobilizing a sample opn the substrate; c) amplifying analyte nucleic acid molecules present within thesample; and d) allowing binding to take place between an amplified analyte nucleic acid, a target molecule immobilized onto the channels of the substrate, and a reporter system, where the reporter system detects whether binding has occurred between the target molecule and the analyte nucleic acid.

Corning has received US Patent No. 7,364,849, “Treatment of substrates for immobilizing biomolecules.” The patent claims a method of non-covalently immobilizing biomolecules on a surface of an array substrate by: a) providing an array substrate that includes a functional group for non-covalent attachment to a biomolecule; b) contacting the surface with a reducing agent; c) attaching a biomolecule to the functional group after the contacting step.

Affymetrix has received US Patent No. 7,364,895, “Bioarray chip reaction apparatus and its manufacture.” The patent claims an apparatus for mixing a fluid that includes: a) a substrate comprising a first inner surface functionalized with a microarray of reactive moieties; b) a substantially parallel second substrate also comprising a second inner surface, where the first and second inner surfaces bind a closed chamber; c) a chamber adapted to retain a quantity of fluid so that the fluid is in contact with both surfaces; d) at least one bubble disposed within the chamber; and e) a means for moving the chamber so that the bubble moves relative to the fluid so that it is mixed.

Agilent Technologies has received US Patent No. 7,364,896, “Test strips including flexible array substrates and method of hybridization.” The patent describes individual and aggregate test strip arrays that support an addressable collection of probes. Hybridization cells for use with the individual test strip arrays are also described, and in particular embodiments the hybridization cells closely fit a portion or all of the individual test strip arrays. Array hybridization systems that include test strip arrays and hybridization cells are also described with methods for performing a hybridization assay on a sample solution.

The Scan

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.

Study Reveals Potential Sex-Specific Role for Noncoding RNA in Depression

A long, noncoding RNA called FEDORA appears to be a sex-specific regulator of major depressive disorder, affecting more women, researchers report in Science Advances.

New mRNA Vaccines Offer Hope for Fighting Malaria

A George Washington University-led team has developed mRNA vaccines for malaria that appear to provide protection in mice, as they report in NPJ Vaccines.

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.