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Massachusetts Institute of Technology, University of Nebraska, and Ludwig Institute for Cancer Research

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Massachusetts Institute of Technology of Cambridge, Mass., has received US Patent No. 6,893,877, "Methods for screening substances in a microwell array." The patent describes methods for manufacturing and using an apparatus for manipulating and analyzing a large number of microscopic samples of a liquid or materials, including cells, in liquid suspension. According to the patented method, parallel through-holes are formed in a plate and loaded with a liquid. Loading may be performed in such a way as to create a gradient, with respect to the position of the through-holes, of the concentration of a particular substance or of another quantity. Mixing of the contents of through-holes may be obtained by bringing filled microwell arrays into contact with each other with registration of individual through-holes and distributing the samples between the arrays.


The University of Nebraska of Lincoln, Neb., has received US Patent No. 6,897,875, "Methods and system for analysis and visualization of multidimensional data." The patented invention is used for analyzing biological data and provides methods and systems for the recognition of patterns and trends in complex multidimensional data using component plane presentations to visualize the data. According to the patent, the visualization method of the invention begins with data that has already been organized into units representing clusters of strongly similar data. Each cluster represented by a map unit is located on a neighborhood map so that clusters that are more similar to each other are nearer to one another spatially on the neighborhood map. In a component plane presentation of the organized data, the map units of the neighborhood map are shaded according to the values of one of the components of each map unit. Data analysis according to the present invention provides an empirical analysis of the data permitting the visualization of one component of the data at a time in order to ascertain patterns in the organization of the data. Preferably, the biological data is obtained from a microarray.


Ludwig Institute for Cancer Research of New York has received US Patent No. 6,897,288, "MAGE-A12 antigenic peptides and uses thereof." The patent describes an invention for using peptides derived from the MAGE-A12 polypeptide to render a diagnosis for MAGE A-12-related disorders, preferably cancer. According to the patent, when presented by an antigen presenting cell having an HLA class I molecule, MAGE-A12 effectively induces the activation and proliferation of CD8+ cytotoxic T lymphocytes. The patent describes a method to render a diagnosis by collecting a sample from a patient, and using protein microarrays that include one or more isolated MAGE-A12 HLA class 1-binding peptides, or functional variants that bind HLA class I molecules, to create a gene expression profile, from which the diagnosis can be made. of New York has received US Patent No. 6,897,288, "MAGE-A12 antigenic peptides and uses thereof." The patent describes an invention for using peptides derived from the MAGE-A12 polypeptide to render a diagnosis for MAGE A-12-related disorders, preferably cancer. According to the patent, when presented by an antigen presenting cell having an HLA class I molecule, MAGE-A12 effectively induces the activation and proliferation of CD8+ cytotoxic T lymphocytes. The patent describes a method to render a diagnosis by collecting a sample from a patient, and using protein microarrays that include one or more isolated MAGE-A12 HLA class 1-binding peptides, or functional variants that bind HLA class I molecules, to create a gene expression profile, from which the diagnosis can be made.

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