LG Electronics of Seoul, South Korea, received US Patent No. 6,623,696, “Biochip, apparatus for detecting biomaterials using the same, and method therefore.” The invention provides a biochip that includes: a substrate having a hole at a central portion, a biomaterial region arranged at a circumferential portion of the top surface of the substrate; and an information region formed on the substrate between the biomaterial region and the center hole. To detect biomaterials using the biochip, a disk-type upper substrate is placed on the top surface of the biochip, where a sample is inserted, and a reaction is accelerated by rotating the biochip. The detection unit analyzes the light emitted from the biomaterials, negating the need for scanning equipment. Analytical information of the biomaterial can be recorded in the biochip.
Roche Diagnostics received US Patent No. 6,627,057, “Microsphere containing sensor.” The patent covers an electrochemical biosensor containing a sensor strip with a substrate containing electrodes and microspheres. The sensor strip allows for a smaller sample volume and maintainance of a more uniform flow profile through the sample channel. The device is for controlling flow and enhancing performance of in vitro diagnostic devices.
Motorola received US Patent No. 6,602,400, “Method for enhanced bio-conjugation events.” The patent covers a system and methods for efficient, high-throughput electrical or electrochemical detection of biomolecules. Specifically, the invention provides an apparatus in which an independent set of electrodes is used to increase the occurrence of a desired bio-conjugation event at a test site. According to the inventors, electrical or electrochemical detection eliminates many of the disadvantages inherent in use of radioactive or fluorescent labels to detect interactions between the probe and target molecules. This process offers a detection technique that is safe, inexpensive, and sensitive, and is not burdened with complex and onerous regulatory requirements.
BD and Nanogen received US Patent No. 6,626,417, “Microfluidic valve and microactuator for a microvalve.” The patent covers a microactuator device that includes a base with at least one electrode pad and a permeation membrane, which is typically a water-permeable membrane that is able to deform by applying an electric charge to the electrode pad. The device can be used for various medical applications including drug delivery.
Illumina received US Patent No. 6,620,584, “Combinatorial decoding of random nucleic acid arrays.” The invention provides methods and compositions for combinatorially decoding arrays. The method includes providing an array composition comprising a substrate with a surface of discrete sites and a population of microspheres of first and second subpopulations, each subpopulation containing an identifier nucleic-acid sequence comprising a primer sequence and a decoder sequence. The method further involves adding to the array a first set of combinatorial decoding probes comprising a priming sequence, at least one decoding nucleotide and a label, and detecting the presence of the label. In addition the invention provides kits comprising a substrate of a surface with discrete sites, a population of microspheres and a decoder probe composition comprising a plurality of probes.