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Large Scale Proteomics, Chromagen, Epoch Biosciences, Cytoplex Biosciences, Affymetrix


Large Scale Proteomics of Germantown, Md., received US Patent No. 6,653,151, “Dry deposition of materials for microarrays using matrix displacement.” The patent covers a system of placement of binding partners on microarrays, where such binding partners contain proteins, nucleic acids, biological cells and other bio-reactive components. The method described by the inventors includes methods for manufacture of microarrays constructed in part by sectioning bundles of tubules or rods containing matrix immobilized bio-reactive molecules to produce large numbers of sample chips. The chips so produced are processed by deposition to microarrays. The deposited chips can then be manipulated to partition the immobilizing matrix away from the bio-reactive molecules contained in the matrix and to place the partitioned molecules onto various surfaces for subsequent analysis, to include binding assays, hybridization reactions, diagnostic methods and a variety of cell interaction-determining methodologies.

Chromagen of San Diego received US Patent No. 6,654,119, “Scanning spectrophotometer for high throughput fluorescence detection.” The patent covers a fluorescence spectrophotometer with an excitation double monochromator, a coaxial excitation/emission light transfer module, and an emission double monochromator. Each monochromator includes a pair of holographic concave gratings mounted to precisely select a desired band of wavelengths from incoming broadband light without using other optical elements, such as mirrors. Selected excitation light is directed into a sample well by a light transfer module that includes a coaxial excitation mirror positioned to direct excitation light directly to the bottom of a well of a multi-well plate. Fluorescence emission light that exits the well opening is collected by a relatively large coaxial emission mirror. The collected emission light is wavelength selected by the emission double monochromator. Selected emission light is detected by a photodetector module.

Epoch Biosciences of Bothell, Wash., received US Patent No. 6,653,473, “Fluorescent quenching detection reagents and methods.” The patent covers a method for creating oligonucleotide probes. The probes can also contain a minor-groove binding group.

Cytoplex Biosciences of Dallas received US Patent No. 6,653,124, “Array-based microenvironment for cell culturing, cell monitoring and drug-target validation.” The patent covers a system for an apparatus and method for cell culture in microchambers that are formed on or adjacent to a substrate. The microchambers are connected by one or more fluid conduits, valves, and reagent reservoirs.

Affymetrix received US Patent No. 6,650,411, “System, method, and product for pixel clocking in scanning of biological materials.” The patent covers a system for scanning probe arrays and includes a scanner, and a radial position generator, and digital storage capacity.


The Scan

US Booster Eligibility Decision

The US CDC director recommends that people at high risk of developing COVID-19 due to their jobs also be eligible for COVID-19 boosters, in addition to those 65 years old and older or with underlying medical conditions.

Arizona Bill Before Judge

The Arizona Daily Star reports that a judge weighing whether a new Arizona law restricting abortion due to genetic conditions is a ban or a restriction.

Additional Genes

Wales is rolling out new genetic testing service for cancer patients, according to BBC News.

Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification

In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.