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Large Scale Proteomics, Chromagen, Epoch Biosciences, Cytoplex Biosciences, Affymetrix


Large Scale Proteomics of Germantown, Md., received US Patent No. 6,653,151, “Dry deposition of materials for microarrays using matrix displacement.” The patent covers a system of placement of binding partners on microarrays, where such binding partners contain proteins, nucleic acids, biological cells and other bio-reactive components. The method described by the inventors includes methods for manufacture of microarrays constructed in part by sectioning bundles of tubules or rods containing matrix immobilized bio-reactive molecules to produce large numbers of sample chips. The chips so produced are processed by deposition to microarrays. The deposited chips can then be manipulated to partition the immobilizing matrix away from the bio-reactive molecules contained in the matrix and to place the partitioned molecules onto various surfaces for subsequent analysis, to include binding assays, hybridization reactions, diagnostic methods and a variety of cell interaction-determining methodologies.

Chromagen of San Diego received US Patent No. 6,654,119, “Scanning spectrophotometer for high throughput fluorescence detection.” The patent covers a fluorescence spectrophotometer with an excitation double monochromator, a coaxial excitation/emission light transfer module, and an emission double monochromator. Each monochromator includes a pair of holographic concave gratings mounted to precisely select a desired band of wavelengths from incoming broadband light without using other optical elements, such as mirrors. Selected excitation light is directed into a sample well by a light transfer module that includes a coaxial excitation mirror positioned to direct excitation light directly to the bottom of a well of a multi-well plate. Fluorescence emission light that exits the well opening is collected by a relatively large coaxial emission mirror. The collected emission light is wavelength selected by the emission double monochromator. Selected emission light is detected by a photodetector module.

Epoch Biosciences of Bothell, Wash., received US Patent No. 6,653,473, “Fluorescent quenching detection reagents and methods.” The patent covers a method for creating oligonucleotide probes. The probes can also contain a minor-groove binding group.

Cytoplex Biosciences of Dallas received US Patent No. 6,653,124, “Array-based microenvironment for cell culturing, cell monitoring and drug-target validation.” The patent covers a system for an apparatus and method for cell culture in microchambers that are formed on or adjacent to a substrate. The microchambers are connected by one or more fluid conduits, valves, and reagent reservoirs.

Affymetrix received US Patent No. 6,650,411, “System, method, and product for pixel clocking in scanning of biological materials.” The patent covers a system for scanning probe arrays and includes a scanner, and a radial position generator, and digital storage capacity.


The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.