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Koninklijke Philips Electronics, Eppendorf Array Technologies, University of Chicago, Agilent Technologies


Koninklijke Philips Electronics of Eindhoven, The Netherlands, has received US Patent No. 7,048,890, "Sensor and method for measuring the areal density of magnetic nanoparticles on a microarray." The patent claims a method and device for the magnetic detection of binding of biological molecules on a biochip. The patent describes a magneto-resistant device that measures an areal density of magnetic nanoparticles on a microarray that are directly or indirectly coupled to a target sample. The sensor device includes a substrate with binding sites able to selectively bind the target sample, and a sensor for detecting the magnetic field of the nanoparticles coupled to the target sample.

Eppendorf Array Technologies of Namur, Belgium, has received US Patent No. 7,049,064, "Method for obtaining a surface activation of a solid support for building biochip microarrays." The patent claims a method for making microarrays comprising the steps of: 1) submitting the surface of a solid support to an oxidation of chemical groups in order to allow the formation of aldehyde functions upon the surface of the support; 2) covalently binding capture molecules designed for detection to the aldeyde functions; 3) identifying the quantification and/or the recovery of the complementary target biological or chemical molecules of interest.

The University of Chicago has received US Patent No. 7,049,073, "Double stranded nucleic acid biochips." The patent claims a method of constructing double-stranded DNA microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a connector that includes a linker for immobilization on a matrix, the patent's abstract states. A non-enzymatic method for synthesizing double-stranded nucleic acids with this novel connector enables the construction of inexpensive and robust dsDNA/dsRNA microarrays.

Agilent Technologies has received US Patent No. 7,049,129, "Electro-optical devices and methods for hybridization and detection." The patent claims an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex and forming a final complex, and a potential means for providing a potential to the final complex to produce a detectable signal indicating the presence of the target after redox reaction, the patent's abstract states. The patented method includes the steps of hybridizing a probe with an attached label to the target to produce an initial complex, adding a metal ion to the initial complex to form a final complex and applying a potential to the final complex to produce a measurable signal.


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