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Koken, Fraunhofer Gesellschaft, Agilent Technologies, Intel, Xencor

Koken of Tokyo has received European Patent No. 1921153, “Cell transfection array for use in transfection.” The patent claims a microarray capable of introducing and expressing nucleic acid in cells. The patent also describes where a microarray including atelocollagen, a gene-introducing agent, and nucleic acid are prepared on a plate.The nucleic acid can be introduced into a cell by seeding cells into which nucleic acids are introduced on the microarray and culturing them without the need of preparing a mixture of viral vectors, nucleic acids and a nucleic acid-introducing agent after culturing cells or the need of adding a nucleic acid-introducing agent and additives, the patent claims.

Fraunhofer Gesellschaft of Munich, Germany, has received European Patent No. 1919623 “Chip-holder for a microfluidic chip”. The patent claims a chip-holder for holding a microfluidic chip that includes the means for detachably fixing the microfluidic chip in the chip-holder and at least one process control device configured to support control or monitoring of a chemical process in the microfluidic chip. The chip-holder is configured so that the process control device and the microfluidic chip are directly and detachably coupled when the microfluidic chip is fixed in the chip-holder. According to the patent, the claimed chip-holder allows the microfluidic chip to easily be removed and exchanged while the process control device can be reused. This reduces running costs of a chemical microreactor system drastically and allows for a very flexible usage of a chemical microreactor system, the patent states.

Agilent Technologies has received European Patent No. 1918838, “Estimation of dynamic range of microarray DNA spike-in data by use of parametric curve-fitting.” The patent claims methods for determining the dynamic and linear range of microarray data. Specifically, a method is described for dynamic range analysis of positive control data for arrays that includes using positive control or spike-in data from a microarray experiment, identifying parameters from the positive control data, applying the parameters to a curve-fitting equation, determining the linear range of the spike-in data, and applying the linear range of the positive control data to the microarray experiment.

Intel has received US Patent No. 7,381,529, “Methods and compositions for detecting nucleic acids using scanning probe microscopy and nanocodes.” The patent claims a method for determining the nucleotide sequence of a nucleic acid. The method includes contacting the nucleic acid with a series of labeled oligonucleotides for binding to the nucleic acid, where each labeled oligonucleotide includes a known nucleotide sequence and a molecular nanocode. The nanocode of isolated labeled oligonucleotides that bind to the nucleic acid is then detected.


Xencor of Monrovia, Calif., has received US Patent No. of Monrovia, Calif., has received US Patent No. 7,379,822, “Protein design automation for protein libraries.” The patent claims methods for generating a secondary library of scaffold protein variants by providing a primary library that includes a rank-ordered list of scaffold protein primary variant sequences. A list of primary variant positions in the primary library is then generated, and a plurality of the primary variant positions is then combined to generate a secondary library of secondary sequences. These sequences may then be optionally synthesized and tested, in a variety of ways. In one embodiment, the library may be put onto an array to make a protein chip to be used in high-throughput screening techniques.

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