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Kenneth Loren Beattie, Regents of the University of Michigan, Quark Biotech


Kenneth Loren Beattie of The Woodlands, Texas, has received US Patent Number 6,426,183, “Oligonucleotide microarrays: direct covalent attachment to glass.” The invention provides an improved method for stably attaching a compound, in particular one with at least one amine and hydroxyl group, to a silaceous or silane-containing substrate, in particular glass, porous silica, or oxidized silicon. The method is especially useful attaching nucleic acid sequences, e.g. oligonucleotide or PCR-generated DNA fragments.


The Regents of the University of Michigan in Ann Arbor have received US Patent Number 6,426,184, “Method and apparatus for chemical and biochemical reactions using photo-generated reagents.” The three inventors are co-founders of Xeotron of Houston, Texas. The patent covers a method for performing chemical or biochemical reactions in solution using in situ-generated photo-products as a reagent. This method has applications in the parallel synthesis of molecular sequence arrays on solid surfaces, such as oligonucleotides and peptides on microarrays. The invention also includes an apparatus for performing light-controlled reactions, where light patterns are generated using a computer and a digital optical projector.


Quark Biotech received US Patent Number 6,403,316, “Isolation of cDNA encoding for secreted or membranal proteins,” in June. The patent provides a method for identifying clones encoding for membrane and secreted proteins by deriving probes from membrane-bound polysomes and free polysomes and performing a microarray-based comparison of the relative abundance of the different RNA species. It also provides a method of augmenting a microarray analysis by utilizing RNA extracted from specific subcellular compartments as templates for DNA probes.

The Scan

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.

Analysis of Endogenous Parvoviral Elements Found Within Animal Genomes

Researchers at PLOS Biology have examined the coevolution of endogenous parvoviral elements and animal genomes to gain insight into using the viruses as gene therapy vectors.

Saliva Testing Can Reveal Mosaic CNVs Important in Intellectual Disability

An Australian team has compared the yield of chromosomal microarray testing of both blood and saliva samples for syndromic intellectual disability in the European Journal of Human Genetics.

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.