Johns Hopkins University, Agilent Technologies, Bio-Rad Laboratories, Packard Bioscience, NGK Insulators | GenomeWeb

The Johns Hopkins University received US Patent No. 6,753,147, “Digital amplification.” The patent covers a method for the identification of pre-defined mutations expected to be present in a minor fraction of a cell population. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. Single molecules can be isolated by dilution and individually amplified; each product is then separately analyzed for the presence of pre-defined mutations.

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