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James Overbeck, Agilent Technologies, Commissariat a l Energie Atomique, Minerva Biotechnologies


James Overbeck, et al, received US Patent No. 6,722,395, “Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays.” The patent covers a method for depositing fluid dots in an array, including a pin, a precise transport mechanism, and a mobile-fluid storage devices to resupply the dropper device.

Agilent Technologies received US Patent No. 6,723,516, “Method for continuously detecting the presence and quantity of analytes in a flowing liquid stream.” The patent covers a method that improves on previous relatively slow processes of resolving and identifying specific compounds. The method involves binding an analyte-specific receptor species to the surface of a piezoelectric substrate, contacting the surface-bound receptor species with the flowing liquid stream, and quantitating the presence of the analyte. A novel apparatus for detecting the presence of an analyte in a liquid chromatography eluant is provided as well.

The Commissariat a l’Energie Atomique of Paris received US Patent No. 6,722,580, “Liquid drop ejection device.” The patent covers a device for the ejection of liquid drops comprising a non-deformable body with a cavity, filled with liquid and at least one output orifice. Additionally, the patent covers a means of transmitting a sufficiently large pulse to the liquid to cause ejection of at least one drop.

Minerva Biotechnologies of Newtown, Mass., received US Patent No. 6,723,517 “Use of self-assembled monolayers to probe the structure of a target molecule.” The patent covers a system for transforming weak binding motifs into a high affinity ligand surface by use of a heterologous self-assembled monolayer as a rigid scaffold to present discrete binding moieties, in a controlled geometry, to a target molecule. At a critical ligand density, the discrete binding moieties simulate a multivalent ligand and promote high-affinity, cooperative binding of the target molecule.

The Scan

WHO Seeks Booster Pause

According to CNN, the World Health Organization is calling for a moratorium on administering SARS-CoV-2 vaccine boosters until more of the world has received initial doses.

For Those Long Legs

With its genome sequence and subsequent RNAi analyses, researchers have examined the genes that give long legs to daddy longlegs, New Scientist says.

September Plans

The New York Times reports that the US Food and Drug Administration is aiming for early September for full approval of the Pfizer-BioNTech SARS-CoV-2 vaccine.

Nucleic Acids Research Papers on Targeting DNA Damage Response, TSMiner, VarSAn

In Nucleic Acids Research this week: genetic changes affecting DNA damage response inhibitor response, "time-series miner" approach, and more.