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James Overbeck, Agilent Technologies, Commissariat a l Energie Atomique, Minerva Biotechnologies

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James Overbeck, et al, received US Patent No. 6,722,395, “Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays.” The patent covers a method for depositing fluid dots in an array, including a pin, a precise transport mechanism, and a mobile-fluid storage devices to resupply the dropper device.


Agilent Technologies received US Patent No. 6,723,516, “Method for continuously detecting the presence and quantity of analytes in a flowing liquid stream.” The patent covers a method that improves on previous relatively slow processes of resolving and identifying specific compounds. The method involves binding an analyte-specific receptor species to the surface of a piezoelectric substrate, contacting the surface-bound receptor species with the flowing liquid stream, and quantitating the presence of the analyte. A novel apparatus for detecting the presence of an analyte in a liquid chromatography eluant is provided as well.


The Commissariat a l’Energie Atomique of Paris received US Patent No. 6,722,580, “Liquid drop ejection device.” The patent covers a device for the ejection of liquid drops comprising a non-deformable body with a cavity, filled with liquid and at least one output orifice. Additionally, the patent covers a means of transmitting a sufficiently large pulse to the liquid to cause ejection of at least one drop.


Minerva Biotechnologies of Newtown, Mass., received US Patent No. 6,723,517 “Use of self-assembled monolayers to probe the structure of a target molecule.” The patent covers a system for transforming weak binding motifs into a high affinity ligand surface by use of a heterologous self-assembled monolayer as a rigid scaffold to present discrete binding moieties, in a controlled geometry, to a target molecule. At a critical ligand density, the discrete binding moieties simulate a multivalent ligand and promote high-affinity, cooperative binding of the target molecule.

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