Ventana Medical Systems of Tucson, Ariz., has received US Patent No. 8,098,956, "Digital microscope slide scanning system and methods." The patent describes a microscope slide scanner for digital pathology applications that provides "high-quality images and automated batch-mode operation at low cost." Also provided is a stitching method that allows for dividing an image into a number of overlapping tiles and reconstituting the image with a magnification without substantial loss of accuracy. The scanner is employed in capturing snapshot images and the method allows for overlapping images captured in consecutive snapshots.
SRU Biosystems of Woburn, Mass., has received US Patent No. 8,101,423, "Label-free high-throughput optical technique for detecting biomolecular interactions." A method of detecting binding of one or more specific binding substances to their respective binding partners is claimed. It includes illuminating a biosensor with light and detecting a first peak wavelength value; applying one or more binding partners to the biosensor, where the binding partners do not comprise detection labels; and illuminating the biosensor with light and detecting a second PWV; where, if the one or more specific binding substances have bound to their respective binding partners, then the second PWV is shifted as compared to the first PWV. The patent also describes a biosensor consisting of a two-dimensional grating; a substrate that supports the grating; where the refractive index of the two-dimensional grating is greater than the refractive index of the substrate; and specific binding substances immobilized on the surface of the two-dimensional grating opposite of the substrate.
The University of Texas of Austin has received US Patent No. 8,101,431, "Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems." A portable instrument is claimed that includes a disposable cartridge, an optical detector, a sample collection device and sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and waste reservoirs. The device is capable of obtaining diagnostic information using cellular- and particle-based analyses and may be used in conjunction with membrane- and particle-based analysis cartridges. Analytes, including proteins and cells and microbes, may be detected using the system, according to the patent.
Affymetrix of Santa Clara, Calif., has received US Patent No. 8,101,737, "Parallel preparation of high fidelity probes in an array format." Methods are provided for fabricating oligonucleotides having free 3'-hydroxyl groups from a high-density oligonucleotide array. Synthesis is initiated with a reverse-orientation RNA monomer that contains an orthogonal 2'-OH protecting group. Following conventional probe synthesis, the 2'-OH protecting group is removed to allow base-induced intramolecular transesterification. The transesterification reaction causes release of the synthesized probe with an authentic 3'-hydroxy functionality, while the 2',3'-cyclic phosphate remains attached to the solid support.
T2 Biosystems of Lexington, Mass., has received US Patent No. 8,102,176, "NMR device for detection of analytes." This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, with each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point-of-care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.