Somalogic of Boulder, Colo., has received US Patent No. 8,071,288, "Methods and reagents for detecting target binding by nucleic acid ligands." Using universal protein stains, proteins bound by nucleic acid ligands may be labeled with a detectable moiety. The methods and reagents are particularly useful for the detection of protein targets bound to multiplexed arrays of nucleic acid ligands. The patent also provides methods for the multiplexed evaluation of photocrosslinking nucleic acid ligands.