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IP Update: PerkinElmer; Erasmus University Medical Center; National Tsing Hua University; and More


PerkinElmer of Waltham, Mass., has received US Patent No. 8,153,367, "Amplified array analysis system." The system supports the analysis of relative unmodified samples, where the system consists of a specific binding pair affixed in an array; a mixture including another specific binding pair capable of binding to the first pair so as to form a pair that is affixed to the support; and a reporter system that produces a detectable signal indicative of the presence of the specific binding pair on the support.

Erasmus University Medical Center of Rotterdam, the Netherlands, has received US Patent No. 8,153,373, "Capture and characterized co-localized chromatin (4C) technology." A method for analyzing the frequency of interaction of a target nucleotide sequence with nucleotide sequences of interest is claimed. It includes providing a sample of cross-linked DNA; digesting the cross-linked DNA with a primary restriction enzyme; ligating the cross-linked nucleotide sequences; reversing the cross linking; digesting the nucleotide sequences with a secondary restriction enzyme; ligating DNA sequences of known nucleotide composition to the available secondary restriction enzyme digestion sites that flank the sequences of interest; amplifying the sequences using at least two oligonucleotide primers, where each primer hybridizes to the DNA sequences that flank the nucleotide sequence of interest; hybridizing the amplified sequences to an array; and determining the frequency of interaction between the DNA sequences.

National Tsing Hua University of Hsinchu, Taiwan, has received US Patent No. 8,153,387, "Method for immobilizing glycoprotein." According to the patent abstract, a surface is provided that is then contacted with a boronic acid. A glycoprotein is then contacted to the boronic acid, where two spatially adjacent hydroxyl groups of a carbohydrate chain form a boronate ester with the boronic acid group of the boronic acid to immobilize the glycoprotein.

Bunge Oils of St. Louis has received US Patent No. 8,153,391, "Hydrolases, nucleic acids encoding them and methods for making and using them." Methods are claimed for making hydrolases, including lipases, saturases, palmitases, and polynucleotides and nucleic acids encoding them. According to the patent, these polypeptides and nucleic acids can be immobilized to an array that in turn can be used to screen for or monitor libraries of compositions for their ability to bind to or modulate the activity of a nucleic acid or a polypeptide. The patent provides the example of how such an array can be used to monitor transcript expression of a hydrolase gene.

Enzo Life Sciences of Farmingdale, NY, has received US Patent No. 8,153,802, "Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules." The dyes provided may be used free in solution where the binding of the dye to the target molecule provides signal generation. The dyes may also include reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. Microarray assays may also be carried out where one component is fixed to a solid support and a corresponding partner is in solution. By binding to the component fixed to the support, the partner becomes attached to the support.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.