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IP Update: Palo Alto Research Center; SQI Diagnostics; Illumina; Sony; Mauna Kea Technologies

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Palo Alto Research Center of Palo Alto, Calif., has received US Patent No. 8,080,221, "Capillary-channel probes for liquid pickup, transportation and dispense using stressy metal." The patent describes fluidic conduits that can be used in microarraying systems, dip pen nanolithography systems, fluidic circuits, and microfluidic systems. The conduits are formed from spring beams, including stressy metal beams, which curve away from the substrate when released, and the channels in the conduits can either be integrated into the spring beams or formed on the spring beams. According to the patent, capillary forces produced by the narrow channels allow liquid to be gathered, held, and dispensed by the channel spring probes.


SQI Diagnostics of Toronto has received US Patent No. 8,080,279, "Method for double-dip substrate spin optimization of coated micro array supports." A method for preparing a coated substrate for use in microarray devices is claimed. It includes applying a first coat to a support and making the substrate coating ramp by subjecting the support to centripetal forces. A second coat is added to the support, which is subjected to centripetal forces for a second time to produce a substrate coated membrane in which the thickness of the substrate layer is uniform across the entire coated surface.


Illumina of San Diego has received US Patent No. 8,080,380, "Use of microfluidic systems in the detection of target analytes using microsphere arrays." A microfluidic device is claimed that consists of a substrate containing wells in fluid communication with a flow channel where the flow channel is capable of receiving fluid flow through an inlet port; a population of beads containing binding ligands, where the beads are divided into two groups, those consisting of nucleic acid and those consisting of enzymes; and an electro-osmotic pump in communication with the flow channel.


Illumina has also received US Patent No. 8,081,792, "Fourier scattering methods for encoding microbeads and methods and apparatus for reading the same." The method includes providing microbeads in a random manner onto a support substrate in a predetermined manner, where each of the microbeads has an individually identifiable code that can be projected on and read from a Fourier plane; illuminating the microbeads with an incident light, where the codes on the microbeads provide corresponding output light signals projected on the Fourier plane; and reading the respective codes from the Fourier plane.


Sony of Tokyo has received US Patent No. 8,080,408, "Bioassay substrate and bioassay method." A sample solution is dripped onto a spot area to which detection substances are fixed and an interaction between the detection substance and a target substance in the sample solution is detected by fluorescent intensity. The substrate includes a predetermined number of the spot areas placed in a well arranged on the surface of the substrate; and a fine uneven structure continuously formed on a bottom surface configuring the spot areas.


Mauna Kea Technologies of Paris has received US Patent No. 8,081,310, "Multimarking fibre-type fluorescence microscopic imaging method and system." According to the methods claimed, a sample is scanned with the aid of an excitation signal; the fluorescent signal emanating from the sample is detected, where the excitation signal and fluorescent signal use the same optical path; the optical path is used to excite at least two fluorophores contained in the sample; and a final image is produced, including areas that are colored according to the at least two fluorophores. The multimarking makes it possible to simultaneously acquire two images in two different wavelength bands.

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