The California Institute of Technology of Pasadena has received US Patent No. 8,129,176, "Integrated active flux microfluidic devices and methods." The claimed device is capable of detecting the presence of molecules, such as polynucleotides, proteins, or antigen/antibody complexes, that are correlated to a hybridization signal from an optically detectable reporter associated with the bound molecules. Hybridization probes are immobilized on a substrate exposed to channels of the device that form a closed loop, for circulation of sample to contact complementary probes.

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