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IP Update: California Institute of Technology; Progenika Biopharma; National Livestock Breeding Center; and More

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California Institute of Technology of Pasadena, Calf., has received US Patent No. 8,124,218, "Microfabricated elastomeric valve and pump systems." A method of fabricating an elastomeric structure is claimed. It includes forming a elastomeric layer on top of a micromachined mold, where the micromachined mold has a raised protrusion that forms a recess extending along a bottom surface of the layer. A second elastomeric layer is then formed on top of a second micromachined mold with a second raised protrusion that forms a second recess extending along a bottom surface of the second layer. The bottom surface of the second elastomeric layer is then bound onto a top surface of the first elastomeric layer, resulting in a control channel in the second recess between the first and second elastomeric layers. The first elastomeric layer is then positioned on top of a planar substrate so that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.


Progenika Biopharmaof Derio, Spain, has received US Patent No. 8,124,331," In vitro method to detect bladder transitional cell carcinoma." The patent claims an in vitro method to detect a bladder transitional cell carcinoma in an individual, to determine the stage or severity of this cancer in the individual or to monitor the effect of therapy administered to an individual with this cancer. The patent also claims a method to screen for, identify, develop, and evaluate the efficacy of therapeutic compounds against this cancer in order to develop new medicinal products, and also agents that inhibit the expression and activity of the FGFR3 protein and the effects of this expression. According to the patent, the quantifying of the complexes formed by antibodies and the FGFR3 protein can be performed using protein microarrays.


National Livestock Breeding Centerof Fukushima, Japan, and Yamagata Prefecture of Yamagata, Japan, have received US Patent No. 8,124,344, "Method of determining an amount of fatty acid contents in bovine intramuscular fat on the basis of genotype of fatty acid synthase gene and method of determining goodness of eating quality of beef on the basis of the results thereof." A method is claimed for determining the amount of fatty acid content in bovine intramuscular fat based on the genotype of fatty acid synthase, which is determined by determining two specific bases. The patent also covers a method of determining whether cattle will produce beef with improved eating quality based on those results. According to the patent, the method is carried out using a DNA chip.


Euroimmun of Lübeck, Germany, has received US Patent No. 8,124,354, "Method and immunoabsorbents for specific detection and absorption of antibodies associated with celiac disease and dermatitis herpetiformis." The present invention relates to fusion peptides that are derived from components of gliadin, as well as to a method and reagents for the serological diagnosis of celiac disease or dermatitis herpetiformis by way of assaying antibodies that are directed against modified gliadin. The invention also relates to methods and pharmaceutical compositions for treating said diseases by specific immunoabsorption of these antibodies. The antibodies can be detected using an immunofluorescence test, microarray, ELISA, luminescence test, blot, radioimmunoassay, Western blot, or dot blot.


CapitalBio and Tsinghua University, both of Beijing, have received US Patent No. 8,124,382, "Methods, microarray, and kits for detection of drug resistance genes in gram-negative bacteria." Arrays containing primer pairs for amplifying drug resistance genes and probes for detection of drug-resistance genes are claimed. Also provided are methods of detecting drug-resistance genes using kits and microarrays.


Danisco of Palo Alto, Calif., has received US Patent No. 8,124,399, "Enhanced protein expression in Bacillus." The patent relates to Gram-positive microorganisms, in particular Bacillus species having enhanced expression of a protein of interest, where chromosomal genes have been inactivated, and preferably where one or more chromosomal genes have been deleted from the Bacillus chromosome. The patent also provides a means for the use of microarrays to screen and identify beneficial mutations.


BioArray Solutions of Warren, NJ, now part of Immucor, has received US Patent No. 8,124,402, "Encoded beads having oligonucleotides attached in arrays on a patterned surface." A method is claimed for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. The light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. According to the patent, the claimed device supports interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. It also enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the patent provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.


Honeywell International of Morristown, NJ, has received US Patent No. 8,124,944, "Microarray reader based on evanescent wave detection and method of reading a microarray." The described reader consists of a light source; beam-shaping elements positioned near the light source; a moving stage supporting the elements; an optical substrate supporting an immobilized microarray; a reaction chamber, in contact with the optical substrate and encapsulating a buffer solution; a heating and cooling component in contact with the reaction chamber; a synchronization circuit; an optical filter; and an imaging sensor, positioned near the optical filter.


Simon Fraser University of Burnaby, Canada, has received US Patent No. 8,124,032, "Microfluidic device and method of using same." The device consists of fluid channels, fluid ports, and a V-shaped particle retention structure. According to the patent, the fluid channel is generally opposite the particle retention structure, fluid ports are located between the fluid channel and the particle retention structure, and the particle retention structure has sloped side walls. The device can be used to monitor, observe, measure, or record a biological parameter of a particle, to separate a single particle from a group of particles, to culture a cell, to treat a particle, and to move a particle back and forth in the device.

The Scan

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