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IP Roundup: Veridex, Genomics USA, Steven Ebstein, Yale University

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Veridex of Raritan, NJ, has received US Patent No. 8,183,353, "Breast cancer prognostics." A method is claimed for assessing the likelihood of a recurrence or metastasis of breast cancer in a patient diagnosed with or treated for breast cancer. The method involves the analysis of a gene expression profile that includes up to 56 genes. Arrays to capture and indicate the presence, absence, or degree of gene expression are also described as are kits that include reagents for conducting the gene expression analysis.


Genomics USA of Hoffman Estates, Ill., has received US Patent No. 8,183,360, "Population scale HLA-typing and uses thereof." A portable system for real-time, population-scale human leukocyte antigen genotyping and allelotyping is claimed. Also provided are HLA gene-specific primers and HLA allele-specific or SNP-specific hybridization probes. A microarray consisting of the hybridization probes is also claimed, as is a kit that includes the HLA gene-specific primers and the microarray.


Steven Ebstein of Newton, Mass., has received US Patent No. 8,184,284, "Laser-processed substrate for molecular diagnostics." A device is described for use in performing a diagnostic assay of an analyte. The device includes a base consisting of a patterned surface that is characterized by structures ranging in scale from 10 to 2,000 nanometers in all three spatial dimensions, and where the pattern is stochastic in all three spatial dimensions. According to the patent, a laser process is used to create a pattern on the surface, where the resulting surface has elevations both above and below the elevation of the pre-patterned surface.


Yale University of New Haven, Conn., has received US Patent No. 8,185,320, "Systems and methods for automated analysis of cells and tissues." A computer-implemented method is provided for localizing and quantitating a biomarker present in individual cells of interest contained in a tissue sample. According to the patent, the method includes incubating the tissue sample on a tissue microarray with a stain that specifically labels the biomarker; obtaining a high-resolution image of the stain to determine stain intensity and location; and localizing and quantitating the biomarker.

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