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IP Roundup: Stanford University, Illumina, Micronit Microfluids

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Stanford University of Palo Alto, Calif., has received US Patent No. 8,524,061, "On-chip hybridization coupled with ITP based purification for fast sequence specific identification." According to the patent, isotachophoresis can be employed to simultaneously focus the target and ligand of an assay into the same ITP focus zone. The target and ligand can bind to each other in the ITP focus zone, and then the resulting bound complex can be detected. The inventors claim that the sensitivity of this approach can be increased by the enhanced concentration of both target and ligand that ITP provides in the focus zone.


Illumina of San Diego has received US Patent No. 8,524,450, "Microvessels, microparticles, and methods of manufacturing and using the same." According to the patent, the microvessels can include a respective microbody and a reservoir core configured to hold a substance in the reservoir core. The microbody can include a material that surrounds the reservoir core and facilitates detection of a characteristic of the substance within the reservoir core. Optionally, the material can be transparent so as to facilitate detection of an optical characteristic of a substance within the reservoir core. The microbody can include an identifiable code associated with the substance. The method can also include determining the corresponding codes of the microvessels.


Micronit Microfluids of Enschede, the Netherlands, has received US Patent No. 8,522,413, "Device and method for fluidic coupling of fluidic conduits to a microfluidic chip, and uncoupling thereof." According to the patent, the fluidic conduits are connected mechanically to a first structural part and the microfluidic chip is carried by a second structural part. The structural parts are moved perpendicularly toward and away from each other by means of a mechanism. The inventors claim that this enables "accurate realization of fluidic coupling and uncoupling without the occurrence of undesirable moments of force and with minimal risk of damage to the fluidic conduits or the connecting openings."

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.