San Diego State University has received US Patent No. 8,268,551, "Sensitive sensing based on optical nonlinear wave mixing." The patent claims techniques for using four-wave mixing in microarrays with sample cells of biological or chemical materials. In one implementation, a DNA microarray is placed in an optical degenerate four-wave mixing system operating at an optical wavelength within an absorption spectral range of the DNA cells to generate a DFWM signal in one DNA cell. The DFWM signal is collected and measured. Next, the microarray is scanned in position to place other DNA cells in the DFWM system to get respective DFWM signals. In another implementation, a microchip is provided to include metal ions chelated in a compound in a solution. A capillary electrophoresis process is performed to separate the metal ions from the compound in the solution. Optical beams are directed to overlap on the microchip in a four-wave mixing configuration to obtain a wave mixing signal. The wave mixing signal is then used to determine a concentration of the metal ions.
Platypus Technologies of Madison, Wis., has received US Patent No. 8,268,614, "Method for assaying cell movement." Methods of assaying cell migration are claimed that include providing cells and an assay device; seeding cells in a discrete area of the assay device; and assaying cell movement with a plate-reading device. According to the patent, the assay device may be a multiwell plate or a slide hosting multiple discrete assay regions.
IBM of Armonk, NY, has received US Patent No. 8,267,011, "Stamp with drainage channels for transferring a pattern in the presence of a third medium." A method is claimed for transferring a pattern from an elastic stamp to a substrate in the presence of a third medium, where a proximity contact is achieved between the stamp and the substrate. According to the patent, the method may be used for printing biological molecules on a surface.
IBM has also received US Patent No. 8,268,563, "Method and apparatus for surface treatment." A method is claimed for producing a monolayer of molecules on a surface by loading a stamp with seed molecules, transferring those seed molecules from the stamp to the surface, and amplifying the seed molecules via an amplifying reaction to produce the monolayer. The method permits the generation of complete monolayers from incomplete or sparse monolayers initially printed on the surface, according to the patent.