Saint Louis University has received US Patent No. 8,431,388, "Three-component biosensors for detecting macromolecules and other analytes." According to the patent, the molecular biosensor generally consists of two epitope-binding agents and an oligonucleotide construct. A method is also claimed that includes contacting an oligonulceotide construct, two epitope-binding agents, and a sample, and detecting whether the epitope-binding agents bind to the oligonucleotide construct.

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