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IP Roundup: Saint Louis University, Sony Micronics


Saint Louis University has received US Patent No. 8,431,388, "Three-component biosensors for detecting macromolecules and other analytes." According to the patent, the molecular biosensor generally consists of two epitope-binding agents and an oligonucleotide construct. A method is also claimed that includes contacting an oligonulceotide construct, two epitope-binding agents, and a sample, and detecting whether the epitope-binding agents bind to the oligonucleotide construct. Binding of the agents to the oligonucleotide construct indicates the presence of target in the sample. According to the inventors, the claimed molecular biosensors are useful in several methods including in the identification and quantification of target molecules.

Micronics (Sony) of Redmond, Wash., has received US Patent No. 8,431,389, "Portable high-gain fluorescence detection system." An instrument is claimed for fluorometric assays in liquid samples. According to the patent, the instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The inventors claim that the system can be used in a number of applications, including microfluidic molecular biological assays based on PCR amplification of target nucleic acids, and fluorometric assays in general.

The Scan

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.

Study Reveals Potential Sex-Specific Role for Noncoding RNA in Depression

A long, noncoding RNA called FEDORA appears to be a sex-specific regulator of major depressive disorder, affecting more women, researchers report in Science Advances.

New mRNA Vaccines Offer Hope for Fighting Malaria

A George Washington University-led team has developed mRNA vaccines for malaria that appear to provide protection in mice, as they report in NPJ Vaccines.

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.