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IP Roundup: Illumina, Enzo Life Sciences, Phylogica, Genomics USA, Agilent, and More

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Chung Yuan Christian University of Tao-Yuan, Taiwan, has received US Patent No. 8,574,498, "Biochip with a three-dimensional mesoporous layer." The claimed biochip consists of a three-dimensional mesoporous layer, where the mesoporous layer is chemically modified to recognize labeling DNAs, proteins, peptides, saccharides, and cells. A method for forming the biochip with a three-dimensional mesoporous layer is also claimed. It includes a blending process, a heating process, a coating process, a gelation process, a drying process, and a surface modification process.


Epicentre Technology (now part of Illumina) of Madison, Wis., has received US Patent No. 8,574,864, "Methods and kits for 3'-end-tagging of RNA." Methods are claimed that enable the dual end-tagging of RNA to prepare libraries for analysis by applications such as next-generation RNA sequencing, qPCR, microarray analysis, or cloning. The patent also claims methods for the enzymatic preparation of 5'-activated, 3'-blocked DNA oligonucleotides from standard, single-stranded DNA oligonucleotides.


Enzo Life Sciences of Farmingdale, NY, has received US Patent No. 8,574,881, "Compositions useful for detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes." Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. According to the patent, the claimed dyes are modified by the addition of charged and polar groups to provide beneficial properties.


Phylogica of Subiaco, Australia, has received US Patent No. 8,575,070, "Methods of constructing and screening libraries of peptide structures." The patent provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. It also provides 30,000 independent fold structures produced by this method and made available as a microarray on a substrate.


Genomics USA of Hofman, Estates, Ill., has received US Patent No. 8,575,325, "Population scale HLA-typing and uses thereof." A portable system for real-time, population-scale human leukocyte antigen genotyping and allelotyping in a field environment is claimed. Also discussed are HLA gene-specific primers and HLA allele-specific or SNP-specific hybridization probes. A microarray containing the probes, and a kit containing the array and the HLA gene-specific primers, is also claimed.


Agilent Technologies has received US Patent No. 8,577,621, "Biopolymer array reading." The claimed method includes reading a different array identifier for each biopolymer array from a tag associated with that array. According to the patent, at least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided.

The Scan

Just Breathing

A new analysis suggests that most Mycobacterium tuberculosis is spread by aerosols from breathing, rather than by coughing, the New York Times reports.

Just Like This One

NPR reports that the World Health Organization has hired a South African biotech company to recreate mRNA vaccine for SARS-CoV-2 that is similar to the one developed by Moderna.

Slow Start

The Wall Street Journal reports that Biogen's Alzheimer's disease treatment had revenues for July through September that totaled $300,000.

Genome Research Papers on Cancer Chromatin, Splicing in the Thymus, Circular RNAs in Cancer

In Genome Research this week: analysis of bivalent chromatin sites, RBFOX splicing factors' role in thymic epithelial cells, and more.