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IP Roundup: FIO, Siliconfile Technologies, Hitachi, Novozymes, Bio-Rad


FIO of Toronto has received US Patent No. 8,360,321, "System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology." According to the patent, a system is used to deconvolve multiplexed fluorescence spectral signals into single-color fluorescence spectra. It relies on a spectral database that contains a parameter set for each of the component spectra, as well as a sliding window technique that deconvolves the multiplexed signal into the component spectra. Encoded and received, the signals are then decoded and identified by their component spectra and contributing fluorophore types.

Siliconfile Technologies of Seoul, Korea, has received US Patent No. 8,361,392, "Biochip having image sensor with back side illumination photodiode." The described biochip contains a biochip layer; and an image sensor layer attached to one surface of the biochip layer and configured to sense light with biochemical reaction information, that is emitted from the biochip layer. According to the patent, the image sensor layer includes light-sensing parts that receive the light that is directed toward a back side of a wafer.

Hitachi of Tokyo has received US Patent No. 8,361,784, "Method of inspecting a DNA chip and apparatus thereof." According to the patent, the method of inspecting the DNA chip is executed by irradiating mutually different positions with excitation lights with the use of an objective lens for a time that is longer than a fluorescent light attenuation time, where the excitation lights include a spot diameter that is smaller than the dimension of each cell. The fluorescent lights are then detected, and the chip is inspected based on the positions and intensities of the fluorescent lights.

Novozymes of Bagsværd, Denmark, has received US Patent No. 8,362,221, "Methods for monitoring multiple gene expression." The patent claims methods for monitoring the differential expression of genes in a first Bacillus cell relative to the expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The patent also describes substrates containing an array of Bacillus licheniformis or Bacillus clausii GSTs.

Bio-Rad Laboratories of Hercules, Calif., has received US Patent No. 8,363,223, "Surface plasmon resonance sensor." The patent describes an SPR sensor that consists of a thin conducting layer formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell, and a fluid-providing flow control apparatus. According to the patent, fluid flow is enabled between the flow channel and the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.