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IP Roundup: Columbia University, MIT, Plexera, Samsung Electronics

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Columbia University of New York has received US Patent No. 8,263,192, "Methods for modifying surfaces." A method is claimed for modifying a surface of a monolayer by a) coating a monolayer on a substrate, where the monolayer is formed by self-assembly of end-surfactant molecules, positioning a photoactive functional group at the air-monolayer interface; and b) exposing the monolayer to radiation, where each organic group of the monolayer contains a first functionality that is not converted to a second functionality upon exposure to acid.


The Massachusetts Institute of Technology of Cambridge, Mass., has received US Patent No. 8,263,335, "Methods for high fidelity production of long nucleic acid molecules with error control." A method is claimed for synthesizing a nucleic acid with a desired sequence and length. It includes providing a solid support having an immobilized nucleic acid; performing a nucleic acid addition reaction to elongate the immobilized nucleic acid by adding a nucleotide or an oligonucleotide to the nucleic acid; determining whether the nucleotide or the oligonucleotide is added to the nucleic acid by detecting whether there is an increase in electrophoretic force applied to the solid support; repeating the addition reaction and determination steps if the nucleotide or the oligonucleotide is not added to the nucleic acid; and continuing until the immobilized nucleic acid has a desired sequence and length.


Plexera of Woodinville, Wash., has received US Patent No. 8,263,377, "Label free kinase assays and reagents." Methods are claimed for measuring the binding specificity, kinetics and affinity of kinase inhibitors indirectly using mass sensing analytical techniques, such as surface plasmon resonance, through the competitive displacement of detectable signal-inducing kinase binding molecule. Methods for preparing such molecules are also discussed.


Samsung Electronics has also received US Patent No. 8,263,386, "Digital bio disc (DBD), DBD driver apparatus, and assay method using the same." A digital bio-disc is claimed that includes a rotatable disk having a rotation axis, where the rotatable disk consists of: a sample inlet; chambers that reserve a buffer solution or a reaction solution; a nitrocellulose membrane where biological materials are arrayed, air holes disposed at both sides of the nitrocellulose membrane to dry the nitrocellulose membrane; hydrophobic channels through which fluid can flow between the sample inlet and the chambers by centrifugal force; a hydrophilic channel formed between the chamber connected to the nitrocellulose membrane; and valve holes formed in a direction parallel to the rotation axis. According to the patent, a cylindrical permanent magnet may placed on the valve holes that is capable of opening and closing the valve hole by moving upward or downward in a direction parallel to the rotation axis.


Samsung Electronics has also received US Patent No. 8,263,532, "Microarray substrate, method of use, and products comprising the microarray substrate." The patent provides a microarray substrate that enhances the immobilization efficiency of a probe biomolecule and reduces non-specific binding of impurities, such as proteins, and of target biomolecules, and furthermore, can simultaneously perform cell lysis, PCR, and probe-target hybridization. According to the patent, the microarray substrate consists of a solid substrate coated with a specific functional residue.

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New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.