Columbia University of New York has received US Patent No. 8,313,903, "Binary DNA probe for fluorescent analysis of nucleic acids." The patent describes binary oligonucleotide probes for nucleic analysis, where probes can be made of DNA or RNA that recognize nucleic acid analytes with "high selectivity under mild conditions" and are sensitive to SNPs without PCR amplification. In a given assay, one group of binary probes indicate that they have hybridized to a particular nucleic analyte by binding to a molecular beacon that gives off a fluorescent signal.

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