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The California Institute of Technology of Pasadena has received US Patent No. 8,354,231, "Methods and systems for detecting and/or sorting targets." The methods provided are based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. Polynucleotide-encoded proteins consist of proteins that specifically bind to a predetermined target as well as an encoding polynucleotide that specifically binds to a substrate polynucleotide that is attached to a substrate.

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