Agilent Technologies of Santa Clara, Calif., has received US Patent No. 8,221,978, "Normalization probes for comparative genome hybridization arrays." A method of selecting a set of normalization probes for use on a comparative genome hybridization array is provided. It includes: selecting a first region of a genome to be evaluated by comparative genome hybridization to produce data; selecting a second region of the genome for normalization of the data, and selecting from a set of candidate probes a sub-set of normalization probes that detect the second region.

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