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IP Roundup: Feb 15, 2011

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Illumina has received US Patent No. 7,887,752, "Chemical reaction monitor." The patent claims methods for monitoring chemical reactions. According to the patent, the systems can include a lighting device, a camera device for obtaining an image of the chemical reaction mixtures, and an analyzer program to process data obtained from the image. Methods of monitoring the progress of chemical reactions using the systems are also described.


LG Life Sciences of Daejeon, Korea, has received US Patent No. 7,887,890, "Method of manufacturing plastic substrate using plasma process and plastic substrate manufactured using the method." The patent claims a method of manufacturing a plastic substrate with lower auto-fluorescence and better specificity. The method includes: (a) preparing a plastic substrate; b) treating the plastic substrate with plasma; and c) treating the plastic substrate with a surface-modifying monomer.


Cornell Research Foundation of Ithaca, NY, has received US Patent No. 7,888,009, "Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays." The patent claims a method for identifying sequences differing by one or more single-base changes, insertions, deletions, or translocations in a number of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. According to the patent, the ligation phase relies on a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support.


Asuragen of Austin, Texas, has received US Patent No. 7,888,010, "Methods and compositions involving microRNA." The patent claims a method for identifying a patient as having a marker for lung cancer by a) analyzing miR-205 expression in a lung tissue sample from a patient suspected of having lung cancer; and b) identifying the patient as having a marker correlated with lung cancer when an increase in miR-205 of at least 50 percent in the lung tissue sample compared to a noncancerous lung tissue sample is determined or identifying the patient as not having the marker when the increase in miR-205 in the lung tissue sample fails to be determined. According to the patent, the analysis of the sample includes: a) labeling miRNA isolated from the lung tissue sample; b) hybridizing the miRNA to an miRNA array; and c) determining miRNA hybridization to the array.


Genisphere of Hatfield, Penn., has received US Patent No. 7,888,018, "Methods and kits for nucleic acid amplification." Methods are provided for amplifying nucleic acid molecules. According to the patent, the nucleic acid molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays.


Roche NimbleGen of Madison, Wis., has received US Patent No. 7,888,106, "Microarrays and method for running hybridization reaction for multiple samples on a single microarray." The patent claims a microarray for multiple sample analysis that does not require an alignment of well walls with corresponding probe sets. The patent also claims methods for building and using such a microarray.


Plexera of Woodinville, Wash., has received US Patent No. 7,889,347, "Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism." The patent claims methods related to surface plasmon imaging. An instrument is provided that includes a semi-circular rail and a driving mechanism. According to the patent, the driving mechanism is attached to a light source mount and a detector mount, and both the light source mount and the detector mount are attached to the semi-circular rail with connectors. Each connector allows the light source mount and detector mount to slide along the rail. The synchronous movement of the light source mount and the detector mount changes the angle of incidence of a light beam from the light source with respect to the plane of the sample surface on the sample stage.

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